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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Genetic variation in the vasopressin receptor 1a gene (AVPR1A) associates with pair-bonding behavior in humans
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Genetic variation in the vasopressin receptor 1a gene (AVPR1A) associates with pair-bonding behavior in humans

机译：血管加压素受体1a基因（AVPR1A）的遗传变异与人类中的成对键合行为相关

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摘要

Pair-bonding has been suggested to be a critical factor in the evolutionary development of the social brain. The brain neuropep-tide arginine vasopressin (AVP) exerts an important influence on pair-bonding behavior in voles. There is a strong association between a polymorphic repeat sequence in the 5' flanking region of the gene (avpria) encoding one of the AVP receptor subtypes (V1aR), and proneness for monogamous behavior in males of this species. It is not yet known whether similar mechanisms are important also for human pair-bonding. Here, we report an association between one of the human AVPR1A repeat polymorphisms (RS3) and traits reflecting pair-bonding behavior in men, including partner bonding, perceived marital problems, and marital status, and show that the RS3 genotype of the males also affects marital quality as perceived by their spouses. These results suggest an association between a single gene and pair-bonding behavior in humans, and indicate that the well characterized influence of AVP on pair-bonding in voles may be of relevance also for humans.
机译：配对键已被认为是社交大脑进化发展的关键因素。大脑神经肽精氨酸加压素（AVP）对田鼠的成对键合行为具有重要影响。编码AVP受体亚型（V1aR）之一的基因（avpria）的5'侧翼区域的多态性重复序列与该物种的雄性一夫一妻制行为的倾向之间存在密切的关联。尚不清楚类似的机制对人类配对是否也重要。在这里，我们报告了人类AVPR1A重复多态性（RS3）之一与反映男性中成对键合行为的性状之间的关联，包括伴侣键合，感知的婚姻问题和婚姻状况，并表明男性的RS3基因型也会影响他们的配偶所感知的婚姻质量。这些结果表明单个基因与人类中的成对键合行为之间存在关联，并表明特征明确的AVP对田鼠中成对键合的影响也可能与人类有关。

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