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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Stathmin Reveals Dissociable Roles Of The Basolateral Amygdala In Parental And Social Behaviors
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Stathmin Reveals Dissociable Roles Of The Basolateral Amygdala In Parental And Social Behaviors

机译：Stathmin揭示了基底外侧杏仁核在父母和社交行为中的分离作用

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Innate parental behaviors and adult social interactions are essential for survival of the individual along with the species as a whole. Because these behaviors require threat assessment of the environment, it is plausible that they are regulated by the amygdala-associated neural circuitry of fear. However, the amygdala is not a single anatomic and functional unit, and nuclei of the amygdala have multiple inter- and intra-connections. This poses a question as to the exact role of different amygdala nuclei in these behaviors and the mechanisms involved. The basolateral complex of the amygdala nuclei (BLA) is particularly interesting in this regard: although the BLA role in forming memories for learned fear is established, the BLA role in innate behaviors is not well understood. We recently demonstrated that mice without an inhibitor of microtubules, stathmin, a gene enriched in BLA-associated circuitry, have deficiency in innate and learned fear. Here we show that the deficiency in fear processing in stathmin~(-/-) females leads to improper threat assessment, which in turn affects innate parental care and adult social interactions. Profound deficiency is observed in maternal behavior of stathmin~(-/-) females: they lack motivation for retrieving pups and are unable to choose a safe location for nest-building. Remarkably, stathmin~(-/-) females have an enhancement in social interactions. BLA lesions in WT mice produce similar effects in maternal and social behaviors, confirming vital BLA participation. The findings implicate stathmin as the critical molecular component linking the BLA-associated neural circuitry with innate parental behaviors and adult social interactions.
机译：先天的父母行为和成年社交互动对于个体以及整个物种的生存至关重要。由于这些行为需要对环境进行威胁评估，因此有可能受到杏仁核相关的恐惧神经回路的调节。然而，杏仁核不是单个的解剖和功能单元，并且杏仁核具有多个内部和内部连接。这就提出了一个问题，即不同的杏仁核在这些行为及其机制中的确切作用。在这方面，杏仁核（BLA）的基底外侧复合体特别有趣：尽管已建立了BLA在形成记忆中的学习恐惧中的作用，但尚未很好地了解BLA在先天行为中的作用。我们最近证明，没有微管抑制剂stathmin（一种富含BLA相关电路的基因）的小鼠先天性和学习性恐惧症均缺乏。在这里，我们表明，在stathmin〜（-/-）女性中恐惧处理的不足会导致不正确的威胁评估，进而影响先天父母的照顾和成人的社交活动。在stathmin〜（-/-）女性的产妇行为中发现了严重的缺陷：她们缺乏取回幼崽的动力，无法选择安全的位置筑巢。值得注意的是，stathmin〜（-/-）女性的社交互动能力得到增强。 WT小鼠中的BLA病变在母体和社交行为中产生相似的作用，证实了重要的BLA参与。这些发现暗示着athathmin是连接BLA相关神经回路与先天父母行为和成人社交互动的关键分子成分。

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