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首页> 外文期刊>The European Journal of Neuroscience >Dissociable effects of cocaine-seeking behavior following D1 receptor activation and blockade within the caudal and rostral basolateral amygdala in rats.
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Dissociable effects of cocaine-seeking behavior following D1 receptor activation and blockade within the caudal and rostral basolateral amygdala in rats.

机译：D1受体激活和大鼠尾侧和足侧基底外侧杏仁核内可卡因寻找行为的可分解作用。

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Research with dopamine D(1) receptor antagonists or neuronal inactivating agents suggests that there is dissociable regulation of cocaine-seeking behavior by the rostral and caudal basolateral amygdala. In the present study, discrete infusions of the D(1) receptor agonist SKF 81297 (0.0-0.8 microg per side) were compared with those of the D(1) receptor antagonist SCH 23390 (0.0-2.0 microg per side) to demonstrate directly the importance of D(1) receptor mechanisms within the rostral and caudal basolateral amygdala for their functional heterogeneity in regulating cocaine-seeking behavior. Under a second-order schedule, cocaine-seeking behavior was studied during maintenance (cocaine and cocaine cues present) and reinstatement (only cocaine cues present). Food-maintained responding was used to examine the specificity of maximal behaviorally effective doses of SKF 81297 and SCH 23390. The results demonstrated that the D(1) agonist (0.4 or 0.8 microg) increased and the D(1) antagonist (1.0 microg) decreased cocaine-seeking behavior during maintenance when infused into the caudal but not the rostral basolateral amygdala. Cocaine intake was not affected by the agonist, and was decreased by the antagonist. During reinstatement, the D(1) agonist (0.4 microg) increased and the D(1) antagonist (1.0 microg) decreased cocaine-seeking behavior when infused into the rostral but not the caudal basolateral amygdala. In tests for behavioral specificity, the above effective doses of SKF 81297 and SCH 23390 used in self-administration experiments did not alter food-maintained responding. However, the 2.0-microg dose of SCH 23390 suppressed drug-maintained and food-maintained responding after infusion into both subregions. Collectively, these findings indicate dissociable sensitivity to D(1) receptor ligands within the caudal and rostral basolateral amygdala for altering cocaine-seeking behavior under different conditions that model phases of addiction.
机译：用多巴胺D（1）受体拮抗剂或神经元灭活剂的研究表明，鼻翼和尾基底外侧杏仁核对可卡因的寻求行为具有可分解的调节。在本研究中，将D（1）受体激动剂SKF 81297（每侧0.0-0.8微克）的离散输注与D（1）受体拮抗剂SCH 23390（0.0-2.0微克每侧）的输注进行了比较，以直接证明在鼻和尾基底外侧杏仁核内的D（1）受体机制对于调节可卡因寻找行为的功能异质性的重要性。根据二阶时间表，研究了维持（可卡因和可卡因提示）和恢复（仅可卡因提示）期间的可卡因寻求行为。食物维持反应用于检查最大行为有效剂量SKF 81297和SCH 23390的特异性。结果表明，D（1）激动剂（0.4或0.8微克）增加，而D（1）拮抗剂（1.0微克）增加。当注入尾端而不是鼻侧基底外侧杏仁核时，维持过程中可卡因的寻找行为降低。可卡因的摄入量不受激动剂影响，而被拮抗剂降低。在恢复过程中，当注入鼻尖而不是尾侧基底外侧杏仁核时，D（1）激动剂（0.4 microg）增加，而D（1）拮抗剂（1.0 microg）减少可卡因的寻找行为。在行为特异性测试中，自我管理实验中使用的上述有效剂量SKF 81297和SCH 23390并未改变食物维持的反应。但是，SCH 23390的2.0微克剂量抑制了两个子区域的输注后药物保持和食物保持的响应。总的来说，这些发现表明，在成瘾阶段的不同条件下，尾部和延髓基底外侧杏仁核中的D（1）受体配体具有可分离的敏感性，可改变寻找可卡因的行为。

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