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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >RNaseE and the other constituents of the RNA degradosome are components of the bacterial cytoskeleton
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RNaseE and the other constituents of the RNA degradosome are components of the bacterial cytoskeleton

机译：RNaseE和RNA降解体的其他成分是细菌细胞骨架的组成部分

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RNaseE is the main component of the RNA degradosome of Escherichia coli, which plays an essential role in RNA processing and decay. Localization studies showed that RNaseE and the other known degradosome components (RNA helicase B, polynucleotide phosphorylase, and enolase) are organized as helical filamentous structures that coil around the length of the cell. These resemble the helical structures formed by the MreB and MinD cytoskeletal proteins. Formation of the RNaseE cytoskeletal-like structure requires an internal domain of the protein that does not include the domains required for any of its known interactions or the minimal domain required for endonuclease activity. We conclude that the constituents of the RNA degradosome are components of the E. coli cytoskeleton, either assembled as a primary cytoskeletal structure or secondarily associated with another underlying cytoskeletal element. This suggests a previously unrecognized role for the bacterial cytoskeleton, providing a mechanism to compartmentalize proteins that act on cytoplasmic components, as exemplified by the RNA processing and degradative activities of the degradosome, to regulate their access to important cellular substrates.
机译：RNaseE是大肠杆菌RNA降解体的主要成分，在RNA加工和衰变中起着至关重要的作用。本地化研究表明，RNaseE和其他已知的降解体成分（RNA解旋酶B，多核苷酸磷酸化酶和烯醇化酶）组织成螺旋状的丝状结构，围绕细胞的长度盘旋。这些类似于由MreB和MinD细胞骨架蛋白形成的螺旋结构。 RNaseE细胞骨架样结构的形成需要蛋白质的内部结构域，该内部结构域不包括任何其已知相互作用所需的结构域或核酸内切酶活性所需的最小结构域。我们得出的结论是，RNA降解体的组成部分是大肠杆菌细胞骨架的组成部分，既可以组装为一级细胞骨架结构，也可以与另一个基础细胞骨架元件相关联。这表明细菌细胞骨架以前未被认识到的作用，提供了一种将作用于细胞质成分的蛋白质区分开的机制，例如通过RNA加工和降解体的降解活性来调节它们进入重要细胞底物的过程。

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