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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >MicroRNA-155 is induced during the macrophage inflammatory response
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MicroRNA-155 is induced during the macrophage inflammatory response

机译：在巨噬细胞炎症反应中诱导MicroRNA-155

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摘要

The mammalian inflammatory response to infection involves the induction of several hundred genes, a process that must be carefully regulated to achieve pathogen clearance and prevent the consequences of unregulated expression, such as cancer. Recently, microRNAs (miRNAs) have emerged as a class of gene expression regulators that has also been linked to cancer. However, the relationship between inflammation, innate immunity, and miRNA expression is just beginning to be explored. In the present study, we use microarray technology to identify miRNAs induced in primary murine macrophages after exposure to polyriboi-nosinic:polyribocytidylic acid or the cytokine IFN-β. miR-155 was the only miRNA of those tested that was substantially up-regulated by both stimuli. It also was induced by several Toll-like receptor ligands through myeloid differentiation factor 88- or TRIF-dependent pathways, whereas up-regulation by IFNs was shown to involve TNF-α autocrine signaling. Pharmacological inhibition of the kinase JNK blocked induction of miR-155 in response to either polyriboinosinicpolyribocytidylic acid or TNF-α, suggesting that miR-155-inducing signals use the JNK pathway. Together, these findings characterize miR-155 as a common target of a broad range of inflammatory mediators. Importantly, because miR-155 is known to function as an oncogene, these observations identify a potential link between inflammation and cancer.
机译：哺乳动物对感染的炎症反应涉及数百个基因的诱导，必须仔细调节这一过程以实现病原体清除并防止表达失调的后果，例如癌症。最近，microRNA（miRNA）成为一类与癌症相关的基因表达调节剂。但是，炎症，先天免疫和miRNA表达之间的关系才刚刚开始探索。在本研究中，我们使用微阵列技术鉴定暴露于多核糖核酸-多核糖基酸或细胞因子IFN-β后在原代鼠巨噬细胞中诱导的miRNA。 miR-155是受测者中唯一被两种刺激上调的miRNA。它也被几种Toll样受体配体通过髓样分化因子88或TRIF依赖性途径诱导，而IFN的上调显示涉及TNF-α自分泌信号传导。激酶JNK的药理抑制作用阻止了对多核糖核酸聚核糖酸或TNF-α的miR-155诱导，这表明miR-155诱导信号使用JNK途径。总之，这些发现将miR-155表征为多种炎症介质的共同靶标。重要的是，由于已知miR-155起癌基因的作用，因此这些发现确定了炎症和癌症之间的潜在联系。

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