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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Circadian variation of blood pressure and the vascular response to asynchronous stress
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Circadian variation of blood pressure and the vascular response to asynchronous stress

机译：血压的昼夜节律变化和对异步压力的血管反应

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摘要

The diurnal variation in the incidence of myocardial infarction and stroke may reflect an influence of the molecular clock and/or the time dependence of exposure to environmental stress. The circa-dian variation in blood pressure and heart rate is disrupted in mice, Bmal1~(-/-), Clock~(mut), and Npas2~(mut), in which core clock genes are deleted or mutated. Although Bmal1 deletion abolishes the 24-h frequency in cardiovascular rhythms, a shorter ultradian rhythm remains. Sympathoadrenal function is disrupted in these mice, which reflects control of enzymes relevant to both synthesis (phenylethanolamine N-methyl transferase) and disposition (monoamine oxidase B and catechol-O-methyl transferase) of cat-echolamines by the clock. Both timing and disruption or mutation of clock genes modulate the magnitude of both the sympathoad-renal and pressor but hot the adrenocortical response to stress. Despite diurnal variation of catecholamines and corticosteroids, they are regulated differentially by the molecular clock. Furthermore, the clock may influence the time-dependent incidence of cardiovascular events by controlling the integration of selective asynchronous stress responses with an underlying circadian rhythm in cardiovascular function.
机译：心肌梗塞和中风发生率的昼夜变化可能反映了分子时钟和/或暴露于环境压力下的时间依赖性的影响。小鼠，Bmal1〜（-/-），Clock〜（mut）和Npas2〜（mut）的血压和心率的昼夜变化被破坏，其中核心时钟基因被删除或突变。尽管Bmal1缺失消除了心血管节律中的24小时频率，但仍然存在较短的Ultradian节律。在这些小鼠中交感肾上腺功能受到破坏，这反映了时钟对猫胆碱胺的合成（苯乙醇胺N-甲基转移酶）和处置（单胺氧化酶B和邻苯二酚-O-甲基转移酶）的相关酶的控制。时钟基因的定时和破坏或突变都调节交感神经-肾和增压的强度，但刺激对压力的肾上腺皮质反应。尽管儿茶酚胺和皮质类固醇的昼夜变化，但它们受到分子钟的差异调节。此外，时钟可以通过控制选择性异步应激反应与心血管功能中潜在的昼夜节律的整合来影响心血管事件的时间依赖性。

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