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Gallium (Ⅲ) triflate catalyzed efficient Strecker reaction of ketones and their fluorinated analogs

机译:三氟甲磺酸镓(Ⅲ)催化酮及其氟化类似物的有效Strecker反应

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摘要

The synthesis of α-aminonitriles and their fluorinated analogs has been carried out in high yield and purity by the Strecker reaction from the corresponding ketones and amines with trimethylsilyl cyanide using gallium triflate in dichloromethane. Monofluoro-, difluro-, or trifluoromethyl groups can be incorporated into the α-aminonitrile product by varying the nature of the fluorinated ketones. Study with various fluorinated and nonfluorinated ketones reveals that the choice of proper catalyst and the solvent system (suitable metal triflates as a catalyst and dichloromethane as a solvent) plays the key role in the direct Strecker reactions of ketones.
机译:使用三氟甲磺酸镓的二氯甲烷溶液,通过相应的酮和胺与三甲基甲硅烷基氰化物的Strecker反应,高产率和高纯度地合成了α-氨基腈及其氟化类似物。通过改变氟化酮的性质,可以将单氟,二氟或三氟甲基结合到α-氨基腈产物中。对各种氟化和非氟化酮的研究表明,选择合适的催化剂和溶剂体系(合适的金属三氟甲磺酸酯作为催化剂,二氯甲烷作为溶剂)在酮的直接Strecker反应中起关键作用。

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