Lysosomal killing of Mycobacterium mediated by ubiquitin-derived peptides is enhanced by autophagy

Sylvie Alonso; Kevin Pethe; David G. Russell; Georgiana E. Purdy

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Lysosomal killing of Mycobacterium mediated by ubiquitin-derived peptides is enhanced by autophagy

机译：自噬增强了泛素衍生肽介导的分枝杆菌溶酶体杀伤

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Mycobacterium tuberculosis parasitizes resting macrophages yet is killed by activated macrophages through both oxidative and non-oxidative mechanisms. Nonoxidative mechanisms are linked to the maturation of the bacteria-containing phagosome into an acidified, hydrolytically active compartment. We describe here a mechanism for killing Mycobacteria in the lysosomal compartment through the activity of peptides generated by the hydrolysis of ubiquitin. The induction of autophagy in infected macrophages enhanced the delivery of ubiquitin conjugates to the lysosome and increased the bactericidal capacity of the lysosomal soluble fraction. The accumulation of ubiquitinated proteins in the autoph- agolysosome provides one possible mechanism behind the antimicrobial activities observed for a range of pathogens in autophagous host cells.

机译：结核分枝杆菌可寄生静止的巨噬细胞，但可通过氧化和非氧化机制被活化的巨噬细胞杀死。非氧化机制与含细菌吞噬体进入酸化，水解活性区室的成熟有关。我们在这里描述了通过泛素水解产生的肽的活性杀死溶酶体区室中的分枝杆菌的机制。在受感染的巨噬细胞中自噬的诱导增强了泛素结合物向溶酶体的递送，并增加了溶酶体可溶级分的杀菌能力。自体溶酶体中泛素化蛋白的积累为自噬宿主细胞中多种病原体所观察到的抗菌活性背后提供了一种可能的机制。

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《Proceedings of the National Academy of Sciences of the United States of America》 |2007年第14期|p.6031-6036|共6页
作者
Sylvie Alonso; Kevin Pethe; David G. Russell; Georgiana E. Purdy;
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作者单位

The National University of Singapore, 119077 Singapore;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
关键词
macrophage; phagosome; tuberculosis; lysosome;

机译：巨噬细胞;吞噬体;结核;溶酶体;

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6. Lysosomal killing of Mycobacterium mediated by ubiquitin-derived peptides is enhanced by autophagy [O] . Sylvie Alonso, Kevin Pethe, David G. Russell, 2007

机译：自噬增强了泛素衍生肽介导的分枝杆菌溶酶体杀伤
7. Lysosomal killing of Mycobacterium mediated by ubiquitin-derived peptides is enhanced by autophagy [O] . Alonso, Sylvie, Pethe, Kevin, Russell, David G., 2007

机译：自噬增强了泛素衍生肽介导的分枝杆菌溶酶体杀伤

Lysosomal killing of Mycobacterium mediated by ubiquitin-derived peptides is enhanced by autophagy

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