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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Protection against Escherichia coli infection by antibody to the Staphylococcus aureus poly-N-acetylglucosamine surface polysaccharide
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Protection against Escherichia coli infection by antibody to the Staphylococcus aureus poly-N-acetylglucosamine surface polysaccharide

机译：金黄色葡萄球菌聚-N-乙酰氨基葡萄糖表面多糖的抗体对大肠杆菌的感染保护

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摘要

Poly-N-acetylglucosamine (PNAG) is a surface polysaccharide produced by Staphylococcus aureus and Staphyloccus epidermidis and is an effective target for opsonic and protective Ab for these two organisms. Recently, it has been found that Escherichia coli produces an exo-polysaccharide, designated polyglucosamine, that is biochemically indistinguishable from PNAG. We analyzed 30 E coli strains isolated from urinary tract and neonatal bloodstream infections for the pga locus, PNAG antigen production, and susceptibility to opsonic killing and protection from lethal infection by Ab to PNAG. Twenty-six of 30 strains carried the pga locus, 25 of 30 expressed immunologically detectable PNAG, and 21 of 30 could be killed by rabbit IgG specific for the deacetylated form of the staphylococcal PNAG. Ab to staphylococcal PNAG protected mice against lethality from five different E. coli strains expressing PNAG. PNAG expression by both Gram-negative and Gram-positive organisms could make this antigen a conserved vaccine target for multiple pathogenic species of bacteria.
机译：聚N-乙酰氨基葡萄糖（PNAG）是金黄色葡萄球菌和表皮葡萄球菌产生的表面多糖，是这两种生物的调理和保护性Ab的有效靶标。最近，已经发现大肠杆菌产生一种外多糖，称为聚葡糖胺，其在生物化学上与PNAG没有区别。我们分析了从泌尿道和新生儿血液感染中分离出的30种大肠杆菌菌株的pga基因座，PNAG抗原产生，对光子杀死的敏感性以及对Ab致PNAG致死性感染的保护作用。 30株中的26株带有pga基因座，30株中有25株表达了免疫学上可检测到的PNAG，而30株中的21株可以被对葡萄球菌PNAG的脱乙酰化具有特异性的兔IgG杀死。葡萄球菌PNAG的抗体可保护小鼠免受五种不同表达PNAG的大肠杆菌的致死性。革兰氏阴性和革兰氏阳性生物均表达PNAG可使该抗原成为多种病原菌的保守疫苗靶标。

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