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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Recruitment of an inhibitory hippocampal network after bursting in a single granule cell
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Recruitment of an inhibitory hippocampal network after bursting in a single granule cell

机译：单个颗粒细胞破裂后招募抑制性海马网络

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摘要

The hippocampal CA3 area, an associational network implicated in memory function, receives monosynaptic excitatory as well as disynaptic inhibitory input through the mossy-fiber axons of the dentate granule cells. Synapses made by mossy fibers exhibit low release probability, resulting in high failure rates at resting discharge frequencies of 0.1 Hz. In recordings from functionally connected pairs of neurons, burst firing of a granule cell increased the probability of glutamate release onto both CA3 pyramidal cells and inhibitory interneurons, such that subsequent low-frequency stimulation evoked biphasic excitatory/inhibitory responses in a CA3 pyramidal cell, an effect lasting for minutes. Analysis of the unitary connections in the circuit revealed that granule cell bursting caused powerful activation of an inhibitory network, thereby transiently suppressing excitatory input to CA3 pyramidal cells. This phenomenon reflects the high incidence of spike-to-spike transmission at granule cell to interneuron synapses, the numerically much greater targeting by mossy fibers of inhibitory inter-neurons versus principal cells, and the extensively divergent output of interneurons targeting CA3 pyramidal cells. Thus, mossy-fiber input to CA3 pyramidal cells appears to function in three distinct modes: a resting mode, in which synaptic transmission is ineffectual because of high failure rates; a bursting mode, in which excitation predominates; and a postbursting mode, in which inhibitory input to the CA3 pyramidal cells is greatly enhanced. A mechanism allowing the transient recruitment of inhibitory input may be important for controlling network activity in the highly interconnected CA3 pyramidal cell region.
机译：海马CA3区是一个与记忆功能有关的关联网络，它通过齿状颗粒细胞的苔藓纤维轴突接收单突触兴奋性和突触抑制性输入。由长满苔藓的纤维制成的突触具有较低的释放概​​率，在0.1 Hz的静态放电频率下会导致较高的故障率。在功能连接的成对神经元的录音中，颗粒细胞的爆发发射增加了谷氨酸释放到CA3锥体细胞和抑制性中间神经元的可能性，因此随后的低频刺激引起了CA3锥体细胞的双相兴奋/抑制反应。效果持续几分钟。对电路中单一连接的分析表明，颗粒细胞的破裂引起了抑制网络的强大激活，从而瞬时抑制了对CA3锥体细胞的兴奋性输入。这种现象反映了粒状细胞之间的突触到突触传递到突触间神经突触的发生率很高，苔藓纤维对间突神经元对主细胞的靶向作用在数值上要大得多，并且突触对CA3锥体细胞的突触神经元的输出也大不相同。因此，输入到CA3锥体细胞的苔藓纤维似乎以三种不同的模式起作用：静止模式，由于高失败率，突触传递无效。突发模式，其中激发占主导地位；以及后突模式，其中大大增强了对CA3锥体细胞的抑制性输入。允许短暂招募抑制性输入的机制对于控制高度互连的CA3锥体细胞区域中的网络活动可能很重要。

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