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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Retinotopic mapping of adult human visual cortex with high-density diffuse optical tomography
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Retinotopic mapping of adult human visual cortex with high-density diffuse optical tomography

机译：高密度漫射光学层析成像技术对成年人类视觉皮层的视网膜定位

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摘要

Functional neuroimaging is a vital element of neuroscience and cognitive research and, increasingly, is an important clinical tool. Diffuse optical imaging is an emerging, noninvasive technique with unique portability and hemodynamic contrast capabilities for mapping brain function in young subjects and subjects in enriched or clinical environments. We have developed a high-performance, high-density diffuse optical tomography (DOT) system that overcomes previous limitations and enables superior image quality. We show herein the utility of the DOT system by presenting functional hemodynamic maps of the adult human visual cortex. The functional brain images have a high contrast-to-noise ratio, allowing visualization of individual activations and highly repeatable mapping within and across subjects. With the improved spatial resolution and localization, we were able to image functional responses of 1.7 cm in extent and shifts of < 1 cm. Cortical maps of angle and eccentricity in the visual field are consistent with retinotopic studies using functional MRI and positron-emission tomography. These results demonstrate that high-density DOT is a practical and powerful tool for mapping function in the human cortex.
机译：功能性神经成像是神经科学和认知研究的重要组成部分，并且日益成为重要的临床工具。漫射光学成像是一种新兴的非侵入性技术，具有独特的便携性和血液动力学对比功能，可绘制年轻受试者以及丰富或临床环境中受试者的脑功能图。我们已经开发出了一种高性能，高密度的漫射光学层析成像（DOT）系统，该系统可以克服以前的局限性并实现卓越的图像质量。我们在这里通过展示成年人类视觉皮层的功能性血流动力学图显示了DOT系统的实用性。功能性大脑图像具有很高的对比度和噪声比，从而可以可视化单个激活，并在对象内部和对象之间具有高度可重复的映射。随着改进的空间分辨率和本地化，我们能够成像范围为1.7 cm且偏移<1 cm的功能响应。视场中角度和偏心率的皮层图与使用功能性MRI和正电子发射断层扫描的视网膜定位研究一致。这些结果表明，高密度DOT是一种实用且功能强大的工具，可映射人体皮质中的功能。

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