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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Protein 4.1 B suppresses prostate cancer progression and metastasis
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Protein 4.1 B suppresses prostate cancer progression and metastasis

机译：蛋白质4.1 B抑制前列腺癌的进展和转移

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摘要

Protein 4.1 B is a 4.1/ezrin/radixin/moesin domain-containing protein whose expression is frequently lost in a variety of human tumors, including meningiomas, non-small-cell lung cancers, and breast carcinomas. However, its potential tumor-suppressive function under in vivo conditions remains to be validated. In a screen for genes involved with prostate cancer metastasis, we found that 4.1B expression is reduced in highly metastatic tumors. Down-regulation of 4.1 B increased the metastatic propensity of poorly metastatic cells in an orthotopic model of prostate cancer. Furthermore, 4.1B-deficient mice displayed increased susceptibility for developing aggressive, spontaneous prostate carcinomas. In both cases, enhanced tumor malignancy was associated with reduced apoptosis. Because expression of Protein 4.1 B is frequently down-regulated in human clinical prostate cancer, as well as in a spectrum of other tumor types, these results suggest a more general role for Protein 4.1 B as a negative regulator of cancer progression to metastatic disease.
机译：蛋白质4.1 B是一种含有4.1 / ezrin / radixin / moesin域的蛋白质，其表达经常在各种人类肿瘤（包括脑膜瘤，非小细胞肺癌和乳腺癌）中丢失。然而，其在体内条件下潜在的肿瘤抑制功能仍有待验证。在筛选涉及前列腺癌转移的基因时，我们发现在高度转移性肿瘤中4.1B表达降低。在前列腺癌的原位模型中，4.1 B的下调增加了转移不良的细胞的转移倾向。此外，4.1B缺陷小鼠表现出发展为侵略性，自发性前列腺癌的易感性。在这两种情况下，恶性肿瘤的增强与凋亡的减少有关。因为在人类临床前列腺癌以及一系列其他肿瘤类型中，蛋白4.1 B的表达经常被下调，所以这些结果表明蛋白4.1 B作为癌症发展为转移性疾病的负调节剂，具有更普遍的作用。

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