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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >RNA polymerase: The most specific damage recognition protein in cellular responses to DNA damage?
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RNA polymerase: The most specific damage recognition protein in cellular responses to DNA damage?

机译：RNA聚合酶：细胞对DNA损伤的反应中最特异性的损伤识别蛋白吗？

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摘要

DNA damage induces a number of cellular responses in human cells, including DNA repair, transcriptional reprogramming, delay of cell cycle progression, and apopto-sis. The most common DNA lesions fall into two broad groups: base lesions and single- and double-strand breaks. Both types of lesions are detected by damage sensors that initiate various response reactions. A central question in understanding these responses is the identity of the damage sensor. The study by Derhei-mer et al. in a recent issue of PNAS, together with previous studies, suggests that RNA polymerase II (RNAP II) stalled at a damaged DNA base may constitute the most specific signal for DNA repair, DNA damage checkpoints, and apoptosis (Fig. 1). We suggest that RNAP II is an ideal damage sensor because it has the highest selectivity of all known DNA damage recognition proteins.
机译：DNA损伤在人细胞中诱导许多细胞反应，包括DNA修复，转录重编程，细胞周期进程延迟和凋亡。最常见的DNA损伤分为两大类：基本损伤和单链和双链断裂。两种类型的病变都由引发各种反应的损伤传感器检测到。理解这些响应的中心问题是损坏传感器的身份。 Derhei-mer等人的研究。最近在PNAS上发表的论文以及先前的研究表明，停滞在受损DNA碱基上的RNA聚合酶II（RNAP II）可能构成了DNA修复，DNA损伤检查点和细胞凋亡的最特异性信号（图1）。我们建议RNAP II是理想的损伤传感器，因为它在所有已知的DNA损伤识别蛋白中具有最高的选择性。

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