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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Gtdap-1 promotes autophagy and is required for planarian remodeling during regeneration and starvation
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Gtdap-1 promotes autophagy and is required for planarian remodeling during regeneration and starvation

机译：Gtdap-1促进自噬，并且在再生和饥饿期间进行涡虫重塑是必需的

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摘要

Remodeling is an integral component of tissue homeostasis and regeneration. In planarians, these processes occur constantly in a simple tractable model organism as part of the animal's normal life history. Here, we have studied the gene Gtdap-1. the planarian ortholog of human death-associated protein-1 or DAP-1. DAP-1, together with DAP-kinase, has been identified as a positive mediator of programmed cell death induced by γ-IFN in HeLa cells. Although the function of DAP-kinase is well characterized, the role of DAP-1 has not been studied in detail. Our findings suggest that Gtdap-1 is involved in autophagy in planarians, and that autophagy plays an essential role in the remodeling of the organism that occurs during regeneration and starvation, providing the necessary energy and building blocks to the neoblasts for cell proliferation and differentiation. The gene functions at the interface between survival and cell death during stress-inducing processes like regeneration and starvation in sexual and asexual races of planarians. Our findings provide insights into the complex interconnections among cell proliferation, homeostasis, and cell death in planarians and perspectives for the understanding of neoblast stem cell dynamics.
机译：重塑是组织动态平衡和再生的重要组成部分。在涡虫中，这些过程在简单易处理的模型生物中不断发生，作为动物正常生活史的一部分。在这里，我们研究了基因Gtdap-1。人类死亡相关蛋白1或DAP-1的涡虫直系同源物。已将DAP-1与DAP激酶一起鉴定为HeLa细胞中由γ-IFN诱导的程序性细胞死亡的阳性介质。尽管DAP激酶的功能已被很好地表征，但DAP-1的作用尚未得到详细研究。我们的发现表明，Gtdap-1参与了涡虫的自噬，并且自噬在再生和饥饿过程中发生的生物重塑中起着至关重要的作用，为新生细胞提供了必要的能量和结构单元，以促进细胞增殖和分化。该基因在压力诱导过程中的存活和细胞死亡之间的界面上起作用，这些过程包括涡虫的有性和无性种族中的再生和饥饿。我们的研究结果提供了洞察平面图中细胞增殖，体内稳态和细胞死亡之间复杂相互关系的见解，并为了解新生胚干细胞动力学提供了见解。

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