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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Circadian rhythmicity mediated by temporal regulation of the activity of p38 MAPK
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Circadian rhythmicity mediated by temporal regulation of the activity of p38 MAPK

机译：时间调节p38 MAPK活性介导的昼夜节律

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摘要

Circadian clocks are composed of central oscillators, input pathways that transduce external information to the oscillators, and output pathways that allow the oscillators to temporally regulate cellular processes. Little is known about the output pathways. In this study, we show that the Neurospora crassa osmosensing MAPK pathway, essential for osmotic stress responses, is a circadian output pathway that regulates daily rhythms in the expression of downstream genes. Rhythmic activation of the highly conserved stress-activated p38-type MAPK [Osmotically Sensi tive-2 (OS-2)] by the N. crassa circadian clock allows anticipation and preparation for hyperosmotic stress and desiccation that begin at sunrise. These results suggest a conserved role for MAPK pathways in circadian rhythmicity.
机译：昼夜节律时钟由中央振荡器，将外部信息传递到振荡器的输入路径以及允许振荡器临时调节细胞过程的输出路径组成。关于输出途径知之甚少。在这项研究中，我们显示了神经孢菌（Nasporus crassa）渗透性MAPK途径，对渗透应激反应至关重要，是一种昼夜节律输出途径，可调节下游基因表达中的日常节律。 Cras昼夜节律钟对高度保守的应激激活的p38型MAPK [Osmotically Sensi tive 2（OS-2）]的节律性激活可以预料和准备从日出开始的高渗应激和干燥。这些结果表明在昼夜节律中MAPK途径的保守作用。

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