Mobile DNA leads to mutation

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Mobile DNA leads to mutation

机译：流动DNA导致突变

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Genomic DNA is not a static repository of base pairs. Short pieces of DNA called transposons can pop out and reinsert themselves in different locations. Mutation, however, can result if a transposon interrupts a gene. Hiroki Kano et al. discovered that the mutation that leads to a specific limb deformity in mice is caused by one such transposon shift. Mice born with missing central digits have a condition, dactylaplasia, that depends on not one, but two genetic loci. The authors investigated how the interactions of these two loci led to missing digits. For a mouse to develop dactylaplasia, the Dac locus must be mutated, and the mouse must also have a recessive allele known as mdac.

机译：基因组DNA不是碱基对的静态存储库。称为转座子的短DNA片段可以弹出并重新插入不同位置。但是，如果转座子中断基因，则可能导致突变。 Kiro Hiroki等。他发现导致小鼠特定肢体畸形的突变是由这种转座子移位引起的。出生时缺少中枢数字的小鼠患有乳糜泻，这不取决于一个，而是取决于两个遗传基因座。作者研究了这两个基因座的相互作用如何导致数字缺失。为了使小鼠发展为乳糜泻，必须对Dac基因座进行突变，并且该小鼠还必须具有一个称为mdac的隐性等位基因。

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《Proceedings of the National Academy of Sciences of the United States of America》 |2007年第48期|p.18875|共1页
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
中图分类自然科学总论;
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Mobile DNA leads to mutation

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