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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Maternal family history of Alzheimer's disease predisposes to reduced brain glucose metabolism
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Maternal family history of Alzheimer's disease predisposes to reduced brain glucose metabolism

机译：阿尔茨海默氏病的母亲家族史易导致脑葡萄糖代谢降低

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摘要

Having a parent affected with late-onset Alzheimer's disease (AD) is a risk factor for developing AD among cognitively normal subjects. We examined whether cognitively normal subjects with a parental family history of AD show cerebral metabolic rate of glucose (CMRglc) reductions consistent with AD as compared with those without a family history and whether there are parent gender effects. Forty-nine 50- to 80-year-old normal subjects were examined who received clinical, neuropsychological, and 2-[~(18)F]fluoro-2-deoxy-D-glucose-positron emission tomography examinations, including 16 subjects with a maternal (FHm) and eight with a paternal (FHp) family history of AD and 25 with no family history (FH~-). FH groups were comparable for demographic and neuropsychological measures. As compared with both FH~- and FHp groups, FHm subjects showed CMRglc reductions in the same regions as clinically affected AD patients, involving the posterior cingulate cortex/precuneus, parietotemporal and frontal cortices, and medial temporal lobes (P ＜ 0.05, corrected for multiple comparisons). These effects remained significant after accounting for possible risk factors for AD, including age, gender, education, apolipoprotein E genotype, and subjective memory complaints. No CMRglc differences were found between FHp and FH~-subjects. This study shows a relationship between reduced CMRglc in AD-vulnerable brain regions and a maternal family history of AD in cognitively normal individuals.
机译：父母患迟发性阿尔茨海默氏病（AD）是认知正常受试者中发展AD的危险因素。我们检查了具有AD父母家族史的认知正常受试者与没有家族史的受试者相比，是否显示出与AD一致的脑葡萄糖代谢葡萄糖（CMRglc）降低，以及是否存在父母性别影响。检查了49名50至80岁的正常受试者，他们接受了临床，神经心理学和2- [〜（18）F]氟-2-脱氧-D-葡萄糖-正电子发射断层显像检查，包括16名受试者一位母亲（FHm）和8位具有AD的父系（FHp）家族史，以及25位无家族史（FH〜-）。 FH组在人口统计学和神经心理学测量方面具有可比性。与FH〜-和FHp组相比，FHm受试者在与临床受影响的AD患者相同的区域表现出CMRglc降低，包括后扣带回皮层/前皮神经，顶颞叶和额叶皮层以及颞颞叶（P ＜0.05，校正为多次比较）。在考虑了AD的可能风险因素（包括年龄，性别，教育程度，载脂蛋白E基因型和主观记忆障碍）后，这些影响仍然很明显。在FHp和FH〜受试者之间未发现CMRglc差异。这项研究表明，AD易患脑区域的CMRglc降低与认知正常个体的AD母体家族史之间存在相关性。

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