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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Regulation of spine morphology and spine density by NMDA receptor signaling in vivo
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Regulation of spine morphology and spine density by NMDA receptor signaling in vivo

机译：NMDA受体信号传导在体内调节脊柱形态和密度

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摘要

Dendritic spines are the major sites of excitatory synaptic transmission in the CNS, and their size and density influence the functioning of neuronal circuits. Here we report that NMDA receptor signaling plays a critical role in regulating spine size and density in the developing cortex. Genetic deletion of the NR1 subunit of the NMDA receptor in the cortex leads to a decrease in spine density and an increase in spine head size in cortical layer 2/3 pyramidal neurons. This process is accompanied by an increase in the presynaptic axon bouton volume and the postsynaptic density area, as well as an increase in the miniature excitatory postsynaptic current amplitude and frequency. These observations indicate that NMDA receptors regulate synapse structure and function in the developing cortex.
机译：树突棘是中枢神经系统中兴奋性突触传递的主要部位，其大小和密度会影响神经元回路的功能。在这里，我们报告NMDA受体信号传导在调节发育中的皮质的脊柱大小和密度中起关键作用。皮质中NMDA受体的NR1亚基的遗传缺失导致皮质层2/3锥体神经元的脊柱密度降低和脊柱头部尺寸增加。该过程伴随着突触前轴突体积和突触后密度区域的增加，以及微型兴奋性突触后电流幅度和频率的增加。这些观察表明，NMDA受体调节发育中的皮层中的突触结构和功能。

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