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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Specific subgroups of Fru~M neurons control sexually dimorphic patterns of aggression in Drosophila melanogaster
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Specific subgroups of Fru~M neurons control sexually dimorphic patterns of aggression in Drosophila melanogaster

机译：Fru〜M神经元的特定亚组控制果蝇的攻击性双态性模式

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摘要

A great challenge facing neuroscience is to understand how genes, molecules, cells, circuits, and systems interact to generate social behavior. Fruit flies (Drosophila melanogaster) offer a powerful model system to address questions of this magnitude. These animals display genetically specified, sexually dimorphic patterns of fighting behavior via sex-specific splicing of the fruitless gene. Here, we show that sexually dimorphic behavioral patterns displayed during aggression are controlled by specific subgroups of neurons expressing male forms of fruitless proteins (Fru~M). Using the GAL4/UAS system to manipulate transformer expression, we feminized or masculinized different populations of neurons in fly nervous systems. With a panneuronal elav-GAL4 driver, male patterns of fighting behavior were transferred into females and female patterns into males. We screened 60 Gal4 lines that express the yeast transcription factor in different patterns in fly central nervous systems and found five that showed abnormal same-sex courtship behavior. The sexually dimorphic fighting patterns, however, were completely switched only in one and partially switched in a second of these lines. In the other three lines, female patterns of aggression were seen despite a switch in courtship preference. A tight correspondence was seen between Fru~M expression and how flies fight in several subgroups of neurons usually expressing these proteins: Expression is absent when flies fight like females and present when flies fight like males, thereby beginning a separation between courtship and aggression among these neurons.
机译：神经科学面临的一大挑战是了解基因，分子，细胞，电路和系统如何相互作用以产生社会行为。果蝇（果蝇（Drosophila melanogaster））提供了一个强大的模型系统来解决这一问题。这些动物通过无结果基因的性别特异性剪接，表现出遗传学上确定的，战斗行为的性别二态模式。在这里，我们表明，在攻击过程中显示的性二态行为模式是由表达无果蛋白（Fru〜M）的雄性形式的神经元的特定亚组控制的。使用GAL4 / UAS系统来操纵转换器的表达，我们女性化或男性化了飞行神经系统中不同数量的神经元。使用全神经elav-GAL4驱动程序，将男性战斗行为模式转换为女性，女性模式转换为男性。我们筛选了60个Gal4品系，这些品系在果蝇中枢神经系统中以不同的模式表达酵母转录因子，并发现了5个显示出异常的同性求爱行为。但是，性二态性战斗模式仅在其中一条线中完全切换，而在另一条线中则部分切换。在其他三行中，尽管求偶偏好发生了变化，但仍然看到了女性的侵略模式。人们观察到Fru〜M表达与果蝇如何在通常表达这些蛋白质的几个神经元亚组中战斗紧密相关：果蝇像雌性一样战斗时，表达不存在；果蝇像雄性一样战斗时，表达就出现了，从而在这些之间开始求爱与攻击之间的分离。神经元。

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