...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Neuroendocrine control of a sexually dimorphic behavior by a few neurons of the pars intercerebralis in Drosophila
【24h】

Neuroendocrine control of a sexually dimorphic behavior by a few neurons of the pars intercerebralis in Drosophila

机译：神经内分泌控制果蝇pars大脑皮层的几个神经元的性二态行为。

获取原文
获取原文并翻译 | 示例
   

获取外文期刊封面封底 >>

       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

In Drosophila, Iocomotor activity is sexually dimorphic and the brain area controlling this dimorphism has been mapped. The neurons of the pars intercerebralis (PI) have been suggested to participate in such differences between males and females. However, the precise physical nature of the dimorphism, the identity of the PI neurons involved, and the nature of the neuronal signal coding the dimorphism remain unknown. In this study, we used a video-tracking paradigm to characterize further the pattern of locomotor activity in Drosophila. We show that the number of activity/inactivity periods (start/stop bouts) is also sexually dimorphic, and that it can be genetically feminized in males. Moreover, the transplantation of PI neurons from a female, or of feminized PI neurons from a donor male into a receiver wild-type male is sufficient to induce the feminization of locomotor behavior, confirming that this tiny cluster of ≈10 neurons is directly responsible for the sexual dimorphism in locomotor activity. Finally, feeding males with fluvastatin, a juvenile hormone (JH) inhibitor, also led to start/stop feminization, and this effect is reversible by the simultaneous application of methoprene, a JH analog, suggesting the existence of a neuroendocrine control, by JH, of such behavioral dimorphism.
机译：在果蝇中，Iocomotor活动是性二态性和控制这种二态性的大脑区域已被映射。有人认为大脑皮间神经元（PI）的神经元参与了男性和女性之间的这种差异。但是，该双态性的精确物理性质，所涉及的PI神经元的身份以及编码该双态性的神经元信号的性质仍然未知。在这项研究中，我们使用视频跟踪范例来进一步表征果蝇中的自发活动模式。我们显示活动/不活动期间（开始/停止回合）的数量也是性二态的，并且可以在男性中通过基因女性化。此外，将雌性的PI神经元或供体的雌性PI神经元移植到受体野生型雄性中足以诱导运动行为的女性化，证实了这约10个神经元的微小簇是直接造成的运动活动中的性二态性。最后，用氟伐他汀（一种少年激素（JH）抑制剂）喂养男性，也会导致女性开始/停止女性化，并且通过同时施用JH类似物甲氧丁烯可逆转这种作用，表明JH存在神经内分泌控制，这种行为二态性。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号