...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >The origin of islet-like cells in Drosophila identifies parallels to the vertebrate endocrine axis
【24h】

The origin of islet-like cells in Drosophila identifies parallels to the vertebrate endocrine axis

机译：果蝇中胰岛样细胞的起源与脊椎动物内分泌轴相似

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Single-cell resolution lineage information is a critical key to understanding how the states of gene regulatory networks respond to cell interactions and thereby establish distinct cell fates. Here, we identify a single pair of neural stem cells (neuroblasts) as progenitors of the brain insulin-producing neurosecretory cells of Drosophila, which are homologous to islet β cells. Likewise, we identify a second pair of neuroblasts as progenitors of the neurosecretory Corpora cardiaca cells, which are homologous to the glucagon-secreting islet α cells. We find that both progenitors originate as neighboring cells from anterior neuroectoderm, which expresses genes orthologous to those expressed in the vertebrate adenohypophyseal placode, the source of endocrine anterior pituitary and neurosecretory hypothalamic cells [Whitlock KE (2005) Trends Endocrinol Metab 16:145-151]. This ontogenic-molecular concordance suggests that a rudimentary brain endocrine axis was present in the common ancestor of humans and flies, where it orchestrated the islet-like endocrine functions of insulin and glu-cagon biology.
机译：单细胞分辨率谱系信息是了解基因调控网络状态如何响应细胞相互作用从而建立独特的细胞命运的关键关键。在这里，我们确定了一对神经干细胞（成神经细胞）作为果蝇大脑胰岛素产生神经分泌细胞的祖细胞，与胰岛β细胞同源。同样，我们鉴定出第二对成神经细胞，作为神经分泌性Corpuscardia细胞的祖细胞，与分泌胰高血糖素的胰岛α细胞同源。我们发现这两个祖细胞都起源于前神经外胚层的邻近细胞，前神经外胚层表达的基因与脊椎动物腺垂体斑中表达的基因直系同源，后者是内分泌垂体和神经分泌性下丘脑细胞的来源[Whitlock KE（2005）Trends Endocrinol Metab 16：145-151 ]。这种本体论-分子的一致性表明，人类和苍蝇的共同祖先存在着一个基本的脑内分泌轴，在这里它协调了胰岛素和胰高血糖素生物学的胰岛样内分泌功能。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号