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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Mammary epithelial-specific disruption of the focal adhesion kinase blocks mammary tumor progression
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Mammary epithelial-specific disruption of the focal adhesion kinase blocks mammary tumor progression

机译：粘着斑激酶的乳腺上皮特异性破坏阻止乳腺肿瘤进展

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摘要

Elevated expression and activation of the focal adhesion kinase (FAK) occurs in a large proportion of human breast cancers. Although several studies have implicated FAK as an important signaling molecule in cell culture systems, evidence supporting a role for FAK in mammary tumor progression is lacking. To directly assess the role of FAK in this process, we have used the Cre/loxP recombination system to disrupt FAK function in the mammary epithelium of a transgenic model of breast cancer. Using this approach, we demonstrate that FAK expression is required for the transition of premalignant hyperplasias to carcinomas and their subsequent metastases. This dramatic block in tumor progression was further correlated with impaired mammary epithelial proliferation. These observations provide direct evidence that FAK plays a critical role in mammary tumor progression.
机译：黏着斑激酶（FAK）的表达和激活水平升高在大部分人类乳腺癌中均会发生。尽管有几项研究表明FAK在细胞培养系统中是重要的信号分子，但仍缺乏支持FAK在乳腺肿瘤进展中起作用的证据。为了直接评估FAK在此过程中的作用，我们已使用Cre / loxP重组系统破坏乳腺癌转基因模型的乳腺上皮中的FAK功能。使用这种方法，我们证明FAK表达是癌前增生向癌及其后续转移的过渡所必需的。肿瘤进展中的这种显着阻断进一步与乳腺上皮增殖受损相关。这些观察结果提供了直接的证据，表明FAK在乳腺肿瘤的进展中起着至关重要的作用。

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