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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >SUMOylation of pontin chromatin-remodeling complex reveals a signal integration code in prostate cancer cells
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SUMOylation of pontin chromatin-remodeling complex reveals a signal integration code in prostate cancer cells

机译：桥蛋白染色质重塑复合物的SUMOylation显示前列腺癌细胞中的信号整合代码

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摘要

Posttranslational modification by small ubiquitin-like modifier (SUMO) controls diverse cellular functions of transcription factors and coregulators and participates in various cellular processes including signal transduction and transcriptional regulation. Here, we report that pontin, a component of chromatin-remodeling complexes, is SUMO-modified, and that SUMOylation of pontin is an active control mechanism for the transcriptional regulation of pontin on androgen-receptor target genes in prostate cancer cells. Biochemical purification of pontin-containing complexes revealed the presence of the Ubc9 SUMO-conjugating enzyme that underlies its function as an activator. Intriguingly, 5α-dihydroxytestosterone treatments significantly increased the SUMOylation of pontin, and SUMOylated pontin showed further activation of a subset of nuclear receptor-dependent transcription and led to an increase in proliferation and growth of prostate cancer cells. These data clearly define a functional model and provide a link between SUMO modification and prostate cancer progression.
机译：通过小的泛素样修饰剂（SUMO）进行的翻译后修饰可控制转录因子和共调节因子的多种细胞功能，并参与各种细胞过程，包括信号转导和转录调控。在这里，我们报道桥蛋白，染色质重塑复合物的一个组成部分，是SUMO修饰的，桥蛋白的SUMOylation是前列腺癌细胞上雄激素受体靶基因上桥蛋白转录调控的一种主动控制机制。含桥蛋白的复合物的生化纯化揭示了Ubc9 SUMO偶联酶的存在，该酶是其激活因子的基础。有趣的是，5α-二羟基睾丸激素治疗显着增加了桥蛋白的SUMO酰化作用，而SUMO酰化的桥蛋白显示出核受体依赖性转录子集的进一步活化，并导致前列腺癌细胞的增殖和生长增加。这些数据清楚地定义了功能模型，并提供了SUMO修饰与前列腺癌进展之间的联系。

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