...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >An intragenic MEF2-dependent enhancer directs muscle-specific expression of microRNAs 1 and 133
【24h】

An intragenic MEF2-dependent enhancer directs muscle-specific expression of microRNAs 1 and 133

机译：基因内依赖MEF2的增强子指导microRNA 1和133的肌肉特异性表达

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The muscle-specific microRNAs, miR-1 and miR-133, play important roles in muscle growth and differentiation. Here, we show that the MEF2 transcription factor, an essential regulator of muscle development, directly activates transcription of a bicistronic primary transcript encoding miR-1-2 and 133a-1 via an intragenic muscle-specific enhancer located between the miR-1-2 and 133a-1 coding regions. This MEF2-dependent enhancer is activated in the linear heart tube during mouse embryogenesis and thereafter controls transcription throughout the atrial and ventricular chambers of the heart. MEF2 together with MyoD also regulates the miR-1-2/-133a-1 intragenic enhancer in the somite myotomes and in all skeletal muscle fibers during embryogenesis and adulthood. A similar muscle-specific intragenic enhancer controls transcription of the miR-1-1/-133a-2 locus. These findings reveal a common architecture of regulatory elements associated with the miR-1/-133 genes and underscore the central role of MEF2 as a regulator of the transcriptional and posttranscriptional pathways that control cardiac and skeletal muscle development.
机译：肌肉特定的microRNA，miR-1和miR-133，在肌肉生长和分化中起重要作用。在这里，我们表明，MEF2转录因子是肌肉发育的必需调节剂，它通过位于miR-1-2之间的基因内肌肉特异性增强子直接激活编码miR-1-2和133a-1的双顺反子初级转录物的转录。和133a-1编码区。这种MEF2依赖性增强子在小鼠胚胎发生过程中在线性心管中被激活，然后控制着整个心房和心室的转录。 MEF2与MyoD一起还在胚胎发生和成年期中调节体节肌细胞和所有骨骼肌纤维中的miR-1-2 / -133a-1基因内增强子。类似的肌肉特异性基因内增强子控制miR-1-1 / -133a-2基因座的转录。这些发现揭示了与miR-1 / -133基因相关的调控元件的通用结构，并强调了MEF2作为控制心脏和骨骼肌发育的转录和转录后途径的调节剂的核心作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号