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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >TEX14 is essential for intercellular bridges and fertility in male mice
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TEX14 is essential for intercellular bridges and fertility in male mice

机译：TEX14对于雄性小鼠的细胞间桥和生育至关重要

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摘要

Cytokinesis in somatic cells concludes with the formation of a midbody, which is abscised to form individual daughter cells. In contrast, germ cell cytokinesis results in a permanent intercellular bridge connecting the daughter cells through a large cytoplasmic channel. During spermatogenesis, proposed roles for the intercellular bridge include germ cell communication, synchronization, and chromosome dosage compensation in haploid cells. Although several essential components of the midbody have recently been identified, essential components of the vertebrate germ cell intercellular bridge have until now not been described. Herein, we show that testis-ex pressed gene 14 (TEX14) is a novel protein that localizes to germ cell intercellular bridges. In the absence of TEX14, intercellular bridges are not observed by using electron microscopy and other markers. Spermatogenesis in Tex14(-/-) mice progresses through the transit amplification of diploid spermatogonia and the expression of early meiotic markers but halts before the completion of the first meiotic division. Thus, TEX14 is required for intercellular bridges in vertebrate germ cells, and these studies provide evidence that the intercellular bridge is essential for spermatogenesis and fertility.
机译：体细胞的胞质分裂以中体的形成结束，该中体缺失形成单个子细胞。相反，生殖细胞的胞质分裂作用导致永久的细胞间桥连接子细胞通过大的细胞质通道。在精子发生过程中，建议的细胞间桥作用包括生殖细胞通讯，同步和单倍体细胞的染色体剂量补偿。尽管最近已鉴定出中体的几个基本组成部分，但迄今为止尚未描述脊椎动物生殖细胞胞间桥的基本组成部分。在这里，我们表明，睾丸表达基因14（TEX14）是一种新型蛋白质，定位于生殖细胞间桥。在没有TEX14的情况下，使用电子显微镜和其他标记物未观察到细胞间桥。 Tex14（-/-）小鼠的精子发生过程通过二倍体精原细胞的转运扩增和早期减数分裂标志物的表达而进行，但在第一个减数分裂分裂完成之前停止。因此，TEX14是脊椎动物生殖细胞中细胞间桥梁所必需的，这些研究提供了证据，证明细胞间桥梁对于精子发生和生育是必不可少的。

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