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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >PR130 is a modulator of the Wnt-signaling cascade that counters repression of the antagonist Naked cuticle
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PR130 is a modulator of the Wnt-signaling cascade that counters repression of the antagonist Naked cuticle

机译：PR130是Wnt信号级联反应的调节剂，可对抗拮抗剂裸角质层的阻遏作用

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摘要

The Wnt-signaling cascade is required for several crucial steps during early embryogenesis, and its activity is modulated by various agonists and antagonists to provide spatiotemporal-specific signaling. Naked cuticle is a Writ antagonist that itself is induced by Writ signaling to keep Writ signaling in check. Little is known about the regulation of this antagonist. We have recently shown that the protein phosphatase 2A regulatory subunit PR72 is required for the inhibitory effect of Naked cuticle on Writ signaling. In the present study, we show that PR130, which has an N terminus that differs from that of PR72 but shares the same C terminus, also interacts with Naked cuticle but instead functions as an activator of the Writ-signaling pathway, both in cell culture and during development. We find that PR130 modulates Writ signal transduction by restricting the ability of Naked cuticle to function as a Writ inhibitor. Our data establish PR130 as a modulator of the Wnt-signaling pathway and suggest a mechanism of Writ signal regulation in which the inhibitory activity of Naked cuticle is determined by the relative level of expression of two transcripts of the same protein phosphatase 2A regulatory subunit.
机译：Wnt信号级联是早期胚胎发生过程中几个关键步骤所必需的，它的活性受到各种激动剂和拮抗剂的调节，以提供时空特异性信号。裸露的角质层是一种Writ拮抗剂，其本身由Writ信号传导诱导，以保持Writ信号的抑制。关于这种拮抗剂的调节知之甚少。我们最近显示蛋白质磷酸酶2A调节亚基PR72是裸角质层对Writ信号传导抑制作用所必需的。在本研究中，我们显示了PR130，其N末端不同于PR72，但具有相同的C末端，也与裸角质层相互作用，但在细胞培养中均充当Writ信号通路的激活剂在开发过程中。我们发现PR130通过限制裸露的角质层作为体液抑制物的功能来调节体液信号转导。我们的数据将PR130建立为Wnt信号通路的调节剂，并提出了Writ信号调节机制，其中裸露角质层的抑制活性由相同蛋白质磷酸酶2A调节亚基的两个转录物的相对表达水平决定。

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