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Profile of Robert M. Stroud

机译:Robert M. Stroud的个人资料

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For a cell, membranes are life-enabling demarcations and barriers that must be crossed, and many specialized proteins and channels play crucial roles in facilitating transport across membranes. One such transmembrane protein, Irel, is responsible for putting the brakes on protein folding run amok. Determining how Irel actually senses and responds to a backlog of unfolded proteins in the en-doplasmic reticulum (ER) has been a focus of structural biologist Robert M. Stroud. Elected to the National Academy of Sciences in 2003, Stroud's joint Inaugural Article (1), published in a previous issue of PNAS with colleague and fellow Academy member Peter Walter, is yet another example of how understanding protein structure leads to an understanding of function.
机译:对于细胞而言,膜是必须跨越生命的界限和障碍,许多专门的蛋白质和通道在促进跨膜运输中起着至关重要的作用。一种这样的跨膜蛋白Irel负责使蛋白折叠运行的系统停止运转。结构生物学家罗伯特·M·斯特劳德(Robert M. Stroud)一直致力于确定Irel如何真正感知和响应内质网(ER)中未折叠蛋白质的积压。斯特劳德在上一期的PNAS上与同事和学院成员彼得·沃尔特(Peter Walter)共同发表的第一篇联合文章(1)当选为美国国家科学院院士,这是理解蛋白质结构如何导致对功能的理解的又一个例子。

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