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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >MGluR2 acts through inhibitory G alpha subunits to regulate transmission and long-term plasticity at hippocampal mossy fiber-CA3 synapses
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MGluR2 acts through inhibitory G alpha subunits to regulate transmission and long-term plasticity at hippocampal mossy fiber-CA3 synapses

机译：MGluR2通过抑制性Gα亚基来调节海马苔藓纤维CA3突触的传递和长期可塑性

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摘要

Presynaptic inhibitory G protein-coupled receptors play a critical role in regulating transmission at a number of synapses in the central and peripheral nervous system. We generated transgenic mice that express a constitutively active form of an inhibitory Ga subunit to examine the molecular mechanisms underlying the actions of one such receptor, metabotropic glutamate receptor (mGluR) 2, at mossy fiber-CA3 synapses in the hippocampus. mGluR2 participates in at least three types of mossy fiber synaptic plasticity, (i) transient suppression of synaptic transmission, (it) long-term depression (LTD), and (iii) inhibition of long-term potentiation (LTP), and we find that inhibitory Ga signaling is sufficient to account for the actions of mGluR2 in each. The fact that constitutively active G alpha(i2) occludes the transient suppression of synaptic transmission by mGluR2, while enhancing LTD, suggests further that these two forms of plasticity are expressed via different mechanisms. In addition, the LTP deficit observed in constitutively active G alpha(i2)-expressing mice suggests that mGluR2 activation may serve as a metaplastic switch to permit the induction of LTD by inhibiting LTP.
机译：突触前抑制性G蛋白偶联受体在调节中枢和周围神经系统中许多突触的传递中起关键作用。我们生成了表达抑制性Ga亚基的组成型活性形式的转基因小鼠，以研究一种这样的受体（代谢型谷氨酸受体（mGluR）2）在海马体的苔藓纤维CA3突触中起作用的分子机制。 mGluR2参与了至少三种类型的苔藓纤维突触可塑性，（i）瞬时抑制突触传递，（it）长期抑制（LTD），以及（iii）抑制长期增强（LTP），我们发现Ga抑制信号足以说明每个mGluR2的作用。组成性活性G alpha（i2）阻止mGluR2瞬时抑制突触传递，同时增强LTD，这一事实进一步表明，这两种可塑性通过不同的机制表达。此外，在组成型活性G alpha（i2）表达小鼠中观察到的LTP缺陷表明，mGluR2激活可能是一种化生转换，可以通过抑制LTP诱导LTD。

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