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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Breakpoint structure reveals the unique origin of an interspecific chromosomal inversion (2La) in the Anopheles gambiae complex
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Breakpoint structure reveals the unique origin of an interspecific chromosomal inversion (2La) in the Anopheles gambiae complex

机译：断点结构揭示了冈比亚按蚊复合体中种间染色体倒置（2La）的独特起源

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摘要

Paracentric chromosomal inversions are major architects of organismal evolution and have been associated with adaptations relevant to malaria transmission in anopheline mosquitoes. The processes responsible for their origin and maintenance, still poorly understood, can be illuminated by analysis of inversion breakpoint sequences. Here, we report the breakpoint structure of chromosomal inversion 2La from the principal malaria vector Anopheles gambiae and its relatives in the A. gambiae complex. The distal and proximal breakpoints of the standard (2L+(a)) arrangement contain gene duplications: full-length genes and their truncated copies at opposite ends. Intact genes without pseudogene copies in the alternative arrangement (2La) imply that 2L+(a) is derived and was viable despite damage to genes, because duplication preserved gene function. A unique origin for the interspecific 2La inversion was challenged previously by indirect genetic evidence, but breakpoint sequences determined from members of the A. gambiae complex strongly suggest their descent from a single event. The derived position of 2L+(a), long considered ancestral in this medically important group, has significant implications for the phylogenetic history and the evolution of vectorial capacity in the A. gambiae complex.
机译：副中心染色体倒位是生物进化的主要构筑物，并且已经与按蚊蚊子中疟疾传播的适应有关。仍然难以理解的负责其起源和维护的过程可以通过反演断点序列的分析来阐明。在这里，我们报道了主要疟疾媒介冈比亚按蚊及其亲戚在冈比亚按蚊中的染色体反转2La的断点结构。标准（2L +（a））排列的远端和近端断点包含基因重复：全长基因及其在相对两端的截短副本。完整基因中没有伪基因拷贝（2La），这意味着2L +（a）可以衍生并且尽管基因受到损害也可以存活，因为重复保留了基因功能。种间2La倒位的独特起源之前曾受到间接遗传学证据的挑战，但从冈比亚曲霉复杂成员确定的断点序列强烈暗示了它们是从单个事件中下降的。 2L +（a）的衍生位置在这个医学上很重要的群体中一直被认为是祖先，它对冈比亚曲霉的系统发育历史和矢量能力的演变具有重要意义。

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