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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Thymic output in aged mice
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Thymic output in aged mice

机译：衰老小鼠的胸腺输出

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摘要

Using GFP to mark recent thymic emigrants (RTEs) in mice carrying a GFP transgene driven by the recombination-activating gene 2 promoter, we demonstrate that RTEs are readily detectable even in 2-year-old mice, despite the fact that the proportion of the peripheral T cell pool comprised of RTEs declines with age. Although the number of RTEs decreases after reaching a peak at 6 weeks of age, thymic output as a function of thymic size is surprisingly age-independent. The CD4:CD8 ratio of RTEs declines with age, partly because of a striking decrease in steady-state proliferation of CD4~+ RTEs in older mice. RTEs in aged mice undergo phenotypic maturation in the lymphoid periphery with delayed kinetics compared with young mice. RTEs from aged mice secrete less IL-2, proliferate less well, and achieve only weak expression of early-activation markers compared with more mature naive peripheral T cells from the same mice. The proportion of GFP~- cells in the CD4~+ and CD8~+ thymic compartments increases with age, partly as a result of leakiness in the aged thymus, allowing reentry of naieve peripheral T cells.
机译：使用GFP标记携带由重组激活基因2启动子驱动的GFP转基因的小鼠中的近期胸腺移出物（RTE），我们证明即使在2岁的小鼠中RTE仍很容易检测到，尽管事实上由RTE组成的外周T细胞池随年龄的增长而下降。尽管在6周龄达到峰值后RTE的数量会减少，但是胸腺输出作为胸腺大小的函数却令人惊讶地与年龄无关。 RTE的CD4：CD8比值随着年龄的增长而下降，部分原因是老年小鼠CD4〜+ RTE的稳态增殖显着下降。与年幼小鼠相比，年老小鼠的RTE在淋巴周围发生表型成熟，动力学延迟。与来自相同小鼠的较成熟的幼稚外周T细胞相比，来自衰老小鼠的RTE分泌较少的IL-2，增殖较少，并且仅实现早期激活标记物的弱表达。 CD4〜+和CD8〜+胸腺区室中GFP_-细胞的比例随着年龄的增长而增加，部分原因是胸腺老化导致渗漏，使幼稚的外周T细胞再次进入。

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