...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Circadian rhythms in gene transcription imparted by chromosome compaction in the cyanobacterium Synechococcus elongatus
【24h】

Circadian rhythms in gene transcription imparted by chromosome compaction in the cyanobacterium Synechococcus elongatus

机译：蓝藻Synchococcus elongatus中染色体紧缩赋予基因转录的昼夜节律

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

In the cyanobacterium Synechococcus elongatus (PCC 7942) the kai genes A, B, and C and the sasA gene encode the functional protein core of the timing mechanism essential for circadian clock regulation of global gene expression. The Kai proteins comprise the central timing mechanism, and the sensor kinase SasA is a primary transducer of temporal information. We demonstrate that the circadian clock also regulates a chromosome compaction rhythm. This chromosome compaction rhythm is both circadian clock-controlled and kai-dependent. Although sasA is required for global gene expression rhythmicity, it is not required for these chromosome compaction rhythms. We also demonstrate direct control by the Kai proteins on the rate at which the SasA protein autophos-phorylates. Thus, to generate and maintain circadian rhythms in gene expression, the Kai proteins keep relative time, communicate temporal information to SasA, and may control access to promoter elements by imparting rhythmic chromosome compaction.
机译：在蓝藻延长球藻（PCC 7942）中，kai基因A，B和C和sasA基因编码对全球基因表达的昼夜节律调节至关重要的计时机制的功能蛋白核心。 Kai蛋白构成了中央计时机制，传感器激酶SasA是时间信息的主要转导者。我们证明昼夜节律时钟也调节染色体紧缩的节奏。这种染色体紧缩节律既是昼夜节律的，又是kai依赖性的。尽管sasA是整体基因表达节律所必需的，但这些染色体紧缩节律不是必需的。我们还证明了Kai蛋白对SasA蛋白自磷酸化率的直接控制。因此，为了产生和维持基因表达中的昼夜节律，Kai蛋白保持相对时间，将时间信息传达给SasA，并可以通过赋予节律性染色体紧缩来控制对启动子元件的访问。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号