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Profile of Rino Rappuoli

机译:Rino Rappuoli的个人资料

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Rino Rappuoli grew up in the shadow of what he describes as a testament to the devastating impact of infectious disease: the unfinished wall of the Siena Cathedral in Siena, Italy. When the plague hit the city in 1348, it slashed the population from 100,000 to 30,000. "It basically shut down one of the most powerful economies of the time, and that momentum was lost forever. I see it as an example of what could happen today with pandemic influenza," says Rappuoli, whose current research focuses on developing a vaccine for avian influenza. Rappuoli, currently the Global Head of Vaccines Research for Novartis Vaccines & Diagnostics (Siena, Italy), was elected as a foreign associate of the National Academy of Sciences in 2005. He has spent his career developing vaccines for pertussis, meningitis, and Helicobacter pylori and is jointly responsible for engineering the carrier protein used in many conjugate vaccines. He is credited with launching the field of reverse vaccinology, the first fruits of which are revealed in his Inaugural Article in this issue of PNAS, where he describes a universal vaccine for serogroup B meningococcus.
机译:里诺·拉普奥利(Rino Rappuoli)在他所描述的阴影中长大,这证明了传染病的毁灭性影响:意大利锡耶纳(Siena)锡耶纳大教堂(Siena Cathedral)未完成的墙。当鼠疫在1348年袭击这座城市时,人口从100,000减少到30,000。 Rappuoli说:“它基本上关闭了当时最强大的经济体之一,这种势头永远消失了。我认为这是当今大流行性流感可能发生的一个例子。”禽流感。 Rappuoli是诺华疫苗与诊断公司全球疫苗研究的负责人(意大利锡耶纳),于2005年当选为美国国家科学院的外国研究员。他的职业生涯是为百日咳,脑膜炎和幽门螺杆菌开发疫苗。并共同负责改造许多偶联疫苗中使用的载体蛋白。他被认为开创了反向疫苗学领域,该领域的第一个成果在本期PNAS的就职论文中得到了揭示,他在其中描述了针对B型脑膜炎球菌的通用疫苗。

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