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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Identification of a receptor necessary for Nogo-B stimulated chemotaxis and morphogenesis of endothelial cells
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Identification of a receptor necessary for Nogo-B stimulated chemotaxis and morphogenesis of endothelial cells

机译：鉴定Nogo-B刺激内皮细胞趋化性和形态发生所必需的受体

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摘要

Nogo isoforms (Nogo-A and -B) have been implicated in regulating neural and cardiovascular functions, such as cell spreading and chemotaxis. Unlike the loop domain (Nogo-66) found in all Nogo isoforms that can interact with a neural-specific Nogo-66 receptor, the receptor for the amino terminus of Nogo-B that mediates vascular function is unknown. Here, we identify a previously uncharacterized Nogo-B receptor specificforthe amino terminus of Nogo-B and show that Nogo-B receptor localizes with the ligand Nogo-B during VEGF and wound healing angiogenesis in vivo, mediates chemotaxis in a heterologous expression system and chemotaxis, and 3D tube formation in native endothelial cells. Thus, identification of this receptor may lead to the discovery of agonists or antagonists of this pathway to regulate vascular remodeling and angiogenesis.
机译：Nogo亚型（Nogo-A和-B）已参与调节神经和心血管功能，例如细胞扩散和趋化性。与在所有可以与神经特异性Nogo-66受体相互作用的Nogo同工型中发现的环结构域（Nogo-66）不同，Nogo-B的氨基末端介导血管功能的受体尚不清楚。在这里，我们确定了Nogo-B氨基末端特异的先前未表征的Nogo-B受体，并表明Nogo-B受体在体内的VEGF和伤口愈合血管生成过程中与配体Nogo-B结合，在异源表达系统中介导趋化性和趋化性以及天然内皮细胞中的3D管形成。因此，鉴定该受体可导致发现该通路的激动剂或拮抗剂以调节血管重塑和血管生成。

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