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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Real-time metabolic imaging
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Real-time metabolic imaging

机译：实时代谢成像

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The endogenous substance pyruvate is of major importance to maintain energy homeostasis in the cells and provides a window to several important metabolic processes essential to cell survival. Cell viability is therefore reflected in the metabolism of pyruvate. NMR spectroscopy has until now been the only noninvasive method to gain insight into the fate of pyruvate in the body, but the low NMR sensitivity even at high field strength has only allowed information about steady-state conditions. The medically relevant information about the distribution, localization, and metabolic rate of the substance during the first minute after the injection has not been obtainable. Use of a hyperpolarization technique has enabled 10-15% polarization of C-13(1) in up to a 0.3 M pyruvate solution. i.v. injection of the solution into rats and pigs allows imaging of the distribution of pyruvate and mapping of its major metabolites lactate and alanine within a time frame of approximate to 10 s. Real-time molecular imaging with MRI has become a reality.
机译：内源性丙酮酸对维持细胞能量稳态至关重要，并为细胞存活所必需的几个重要的代谢过程提供了一个窗口。因此，细胞活力反映在丙酮酸的代谢中。迄今为止，NMR光谱学是唯一了解人体丙酮酸命运的非侵入性方法，但是即使在高场强下，较低的NMR灵敏度也只能提供有关稳态条件的信息。尚未获得有关注射后第一分钟内该物质的分布，定位和代谢率的医学相关信息。使用超极化技术可以使C-13（1）在高达0.3 M的丙酮酸溶液中极化10-15％。 i.v.将溶液注入大鼠和猪后，可在大约10 s的时间内对丙酮酸的分布进行成像，并绘制其主要代谢产物乳酸和丙氨酸的图谱。使用MRI进行实时分子成像已成为现实。

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