Real-time optical redox imaging of cartilage metabolic response to mechanical loading

Walsh S. K.; Skala M. C.; Henak C. R.

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Real-time optical redox imaging of cartilage metabolic response to mechanical loading

机译：实时光学氧化还原成像对机械荷载作用

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Objective: Metabolic dysregulation has recently been identified as a key feature of osteoarthritis. Mechanical overloading has been postulated as a primary cause of this metabolic response. Current methods of real-time metabolic activity analysis in cartilage are limited and challenging. However, optical redox imaging leverages the autofluorescence of co-enzymes NAD(P)H and FAD to provide dye-free real-time analysis of metabolic activity. This technique has not yet been applied to cartilage. This study aimed to assess the effects of a compressive load on cartilage using optical redox imaging.

机译：目的：最近已被鉴定为骨关节炎的关键特征。机械超载已被假定为这种代谢反应的主要原因。软骨中实时代谢活性分析的目前的方法是有限的，有限的。然而，光学氧化还原成像利用共酶NAD（P）H的自发荧光，并以提供的代谢活性提供无染料的实时分析。该技术尚未应用于软骨。本研究旨在利用光学氧化还原成像来评估软骨上压缩载荷的影响。

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《Osteoarthritis and cartilage》 |2019年第12期|共10页
作者
Walsh S. K.; Skala M. C.; Henak C. R.;
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作者单位

Univ Wisconsin Comparat Biomed Sci Program Madison WI USA;

Morgridge Inst Res Madison WI USA;

Univ Wisconsin Dept Biomed Engn 3031 Mech Engn Bldg 1513 Univ Ave Madison WI 53706 USA;

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正文语种 eng
中图分类骨科学（运动系疾病、矫形外科学）;
关键词
Articular cartilage; Metabolism; Glycolysis; Oxidative phosphorylation; Redox; Mechanical loading;

机译：关节软骨;新陈代谢;糖酵解;氧化磷酸化;氧化还原;机械载荷;

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专利

1. Real-time optical redox imaging of cartilage metabolic response to mechanical loading [J] . Walsh S. K., Skala M. C., Henak C. R. Osteoarthritis and cartilage . 2019,第12期

机译：实时光学氧化还原成像对机械荷载作用
2. Mechanobiology of Cartilage Impact Via Real-Time Metabolic Imaging [J] . Walsh Shannon K., Shelley Joshua C., Henak Corinne R. Journal of biomechanical engineering. . 2020,第10期

机译：通过实时代谢成像的软骨撞击力学
3. Movement efficiency profile affects knee loading responses to a controlled acute exposure to high metabolic and mechanical training load [J] . Barnett Frank, Troy Blackburn, Claudio Battaglini, Physical therapy in sport: official journal of the Association of Chartered Physiotherapists in Sports Medicine . 2017,第期

机译：运动效率曲线会影响膝关节响应对高代谢和机械训练负荷的受控急性暴露
4. Nonlinear optical molecular imaging enables metabolic redox sensing in tissue-engineered constructs [C] . Leng-Chun Chen, William R. Lloyd, Robert H. Wilson, Molecular imaging III . 2011

机译：非线性光学分子成像可在组织工程构造中实现代谢氧化还原感测
5. Imaging the Microscale Mechanical Response of Articular Cartilage in Early Stage Osteoarthritis Treatments [D] . Irwin, Rebecca Marie. 2020

机译：在早期骨关节炎治疗中的关节软骨微观机械响应成像
6. Simultaneous tractography and elastography imaging of the zone-specific structural and mechanical responses in articular cartilage under compressive loading [O] . Mohammadreza Ravanfar, Gang Yao 2019

机译：压缩载荷下关节软骨区域特定结构和机械反应的同时束线和弹性成像
7. Real-time optical redox imaging of cartilage metabolic response to mechanical loading [O] . S.K. Walsh, M.C. Skala, C.R. Henak 2019

机译：用于机械负荷的软骨代谢反应的实时光学氧化还原成像

Real-time optical redox imaging of cartilage metabolic response to mechanical loading

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