• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Ecological and immunological determinants of dengue epidemics
【24h】

Ecological and immunological determinants of dengue epidemics

机译：登革热流行的生态和免疫学决定因素

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The management of infectious diseases is an increasingly important public health issue, the effective implementation of which is often complicated by difficulties in teasing apart the relative roles of extrinsic and intrinsic factors influencing transmission. Dengue, a vector-borne strain polymorphic disease, is one such infection where transmission dynamics are affected by environmental variables as well as immune-mediated serotype interactions. To understand how alternative hypotheses concerning dengue infection and transmission may explain observed multiannual cycles in disease incidence, we adopt a theoretical approach that combines both ecological and immunological mechanisms. We demonstrate that, contrary to perceived wisdom, patterns generated solely by anti body-dependent enhancement or heterogeneity in virus virulence are not consistent with serotype-specific notification data in important ways. Furthermore, to generate epidemics with the characteristic signatures observed in data, we find that a combination of seasonal variation in vector demography and, crucially, a short-lived period of cross-immunity is sufficient. We then show how understanding the persistence and eradication of dengue serotypes critically depends on the alternative assumed mechanisms.
机译：传染病的管理已成为一个日益重要的公共卫生问题，有效地实施传染病常常由于难以分辨影响传播的外在因素和内在因素的相对作用而变得复杂。登革热是一种媒介传播的菌株多态性疾病，这种感染的传播动态受到环境变量以及免疫介导的血清型相互作用的影响。为了了解有关登革热感染和传播的其他假设如何解释疾病发病率的多年周期，我们采用了一种结合了生态和免疫机制的理论方法。我们证明，与感知到的智慧相反，仅由抗体依赖性增强或病毒毒力的异质性生成的模式在重要方面与血清型特定的通知数据不一致。此外，要生成具有在数据中观察到的特征性特征的流行病，我们发现矢量人口统计学中季节性变化的组合以及至关重要的是，短时间的交叉免疫就足够了。然后，我们展示了如何理解登革热血清型的持久性和根除关键地取决于替代性假设的机制。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号