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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Regulation of T cell activation and tolerance by PDL2
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Regulation of T cell activation and tolerance by PDL2

机译：PDL2对T细胞活化和耐受的调节

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摘要

T cell activation and tolerance are regulated by costimulatory molecules. Although PD-1 serves as a crucial negative regulator of T cells, the function of its ligands, PDL1 and PDL2, is still controversial. In this study, we created a PDL2-deficient mouse to characterize its function in T cell activation and tolerance. Antigen-presenting cells from PDL2-/- mice were found to be more potent in activation of T cells in vitro over the wild-type controls, which depended on PD-1. Upon immunization with chicken ovalbumin, PDL2-/- mice exhibited increased activation of CD4(+) and CD8(+) T cells in vivo when compared with WT animals. In addition, T cell tolerance to an oral antigen was abrogated by the lack of PDL2. Our results thus demonstrate that PDL2 negatively regulates T cells in immune responses and plays an essential role in immune tolerance.
机译：T细胞的活化和耐受性受共刺激分子的调节。尽管PD-1是T细胞的关键负调节剂，但其配体PDL1和PDL2的功能仍存在争议。在这项研究中，我们创建了一个PDL2缺陷小鼠来表征其在T细胞激活和耐受中的功能。发现来自PDL2-/-小鼠的抗原呈递细胞在体外激活T细胞上比依赖于PD-1的野生型对照更有效。鸡卵清蛋白免疫后，与野生型动物相比，PDL2-/-小鼠体内CD4（+）和CD8（+）T细胞的激活增加。另外，缺乏PDL2消除了对口服抗原的T细胞耐受性。因此，我们的结果证明PDL2负调节免疫反应中的T细胞，并在免疫耐受中起重要作用。

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