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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Robust, bistable patterning of the dorsal surface of the Drosophila embryo
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Robust, bistable patterning of the dorsal surface of the Drosophila embryo

机译：果蝇胚胎背表面的稳固，双稳态模式

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摘要

In many developing systems, the fate of a cell is determined by its position in a time-independent spatial distribution of a morphogen. However, during dorsal-ventral patterning in the Drosophila embryo, an initial low-level signal refines to a narrow, high-intensity band. This refinement suggests that cells respond to the local transient morphogen distribution that results from interactions between bone morphogenetic proteins (BMPs), their receptors, the BMP-binding proteins Sog and Tsg, the metalloprotease Tld, and a putative, positively regulated component that locally enhances surface binding of BMPs within the region of high signaling. We develop a computational model for dorsal surface patterning and show that, when positive feedback of a cell surface BMP-binding protein is incorporated, bistability in the kinetic interactions transduces the transient BMP distribution into a switch-like spatial distribution of the BMP-bound receptor. We also show that the inclusion of positive feedback leads to the observed contraction of signaling, because cells near the dorsal midline outcompete adjacent lateral cells for limited amounts of BMP. In the model, cells interpret the morphogen distribution by differentiating according to the history of their exposure rather than to a threshold concentration in a static spatial gradient of the morphogen.
机译：在许多发育中的系统中，细胞的命运取决于其在形态发生子的时间无关的空间分布中的位置。但是，在果蝇胚胎的背腹模式中，最初的低电平信号会细化为狭窄的高强度带。这种改进表明细胞对骨形态发生蛋白（BMP），其受体，BMP结合蛋白Sog和Tsg，金属蛋白酶Tld以及可能局部增强的假定的正调控成分之间相互作用产生的局部瞬时形态发生素响应高信号区域内BMP的表面结合。我们开发了用于背表面构图的计算模型，并表明，当结合细胞表面BMP结合蛋白的正反馈时，动力学相互作用中的双稳态将瞬时BMP分布转换为BMP结合受体的开关状空间分布。我们还表明，包括正反馈会导致观察到的信号收缩，因为在背侧中线附近的细胞在有限的BMP量上胜过相邻的外侧细胞。在该模型中，细胞通过根据其暴露史进行区分，而不是根据形态发生剂的静态空间梯度中的阈值浓度来区分形态发生剂的分布。

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