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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Broad-spectrum biofilm inhibition by a secreted bacterial polysaccharide
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Broad-spectrum biofilm inhibition by a secreted bacterial polysaccharide

机译：分泌的细菌多糖对广谱生物膜的抑制作用

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The development of surf ace-attached biofilm bacterial communities is considered an important source of nosocomial infections. Recently, bacterial interference via signaling molecules and surface active compounds was shown to antagonize biofilm formation, suggesting that nonantibiotic molecules produced during competitive interactions between bacteria could be used for biofilm reduction. Hence, a better understanding of commensal/pathogen interactions within bacterial community could lead to an improved control of exogenous pathogens. To reveal adhesion or growth-related bacterial interference, we investigated interactions between uropathogenic and commensal Escherichia coli in mixed in vitro biofilms. We demonstrate here that the uropathogenic strain CFT073 and all E. coli expressing group II capsules release into their environment a soluble polysaccharide that induces physicochemical surface alterations, which prevent biofilm formation by a wide range of Gram-positive and Gram-negative bacteria. We show that the treatment of abiotic surfaces with group II capsular polysaccharides drastically reduces both initial adhesion and biofilm development by important nosocomial pathogens. These findings identify capsular polymers as antiadhesion bacterial interference molecules, which may prove to be of significance in the design of new strategies to limit biofilm formation on medical in dwelling devices.
机译：附着有冲浪的生物膜细菌群落的发展被认为是医院感染的重要来源。最近，细菌通过信号分子和表面活性化合物的干扰被证明可以拮抗生物膜的形成，这表明在细菌之间的竞争性相互作用过程中产生的非抗生素分子可用于生物膜的还原。因此，对细菌群落内共生/病原体相互作用的更好理解可以导致对外源病原体的更好控制。为了揭示粘附或生长相关的细菌干扰，我们调查了混合体外生物膜中尿毒症和共生大肠杆菌之间的相互作用。我们在这里证明，尿毒症毒株CFT073和所有表达大肠杆菌的II类胶囊均向其环境释放了可溶性多糖，该多糖诱导了理化表面的改变，从而阻止了由广泛的革兰氏阳性和革兰氏阴性细菌形成的生物膜。我们显示，用II类荚膜多糖对非生物表面的治疗可大大减少重要的医院内病原体的初始粘附和生物膜形成。这些发现将荚膜聚合物确定为抗粘附细菌干扰分子，这可能在设计新的策略以限制居住设备中的医用生物膜形成中具有重要意义。

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