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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Impaired collagen chaperone results in preterm PROM
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Impaired collagen chaperone results in preterm PROM

机译：胶原蛋白伴侣受损导致早产

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摘要

It is well known that risk for many polygenic diseases, such as coronary heart disease, hypertension, prostate cancer, and asthma, varies according to race, ethnicity, or population. This phenomenon has led to the suggestion that mapping by admixture linkage disequilibrium (MALD) may hold the power to elucidate the mutations that underlie these common and complex chronic diseases. However, the concept of race is ill-defined because self-reported racial descriptors are often not accurate indicators of ancestry and are frequently confounded with so-ciocultural factors that underlie the risk of disease.
机译：众所周知，许多多基因疾病（如冠心病，高血压，前列腺癌和哮喘）的风险因种族，种族或人口而异。这种现象导致提出这样的建议，即通过混合键不平衡（MALD）进行作图可能具有阐明这些常见和复杂的慢性疾病基础突变的能力。但是，种族的概念定义不清，因为自我报告的种族描述词通常不是血统的准确指标，并且经常与构成疾病风险的社会文化因素混为一谈。

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