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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Differences in vertebrate microRNA expression
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Differences in vertebrate microRNA expression

机译：脊椎动物microRNA表达的差异

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摘要

MicroRNAs (miRNAs) attenuate gene expression by means of translational inhibition and mRNA degradation. They are abundant, highly conserved, and predicted to regulate a large number of transcripts. Several hundred miRNA classes are known, and many are associated with cell proliferation and differentiation. Many exhibit tissue-specific expression, which aids in evaluating their functions, and it has been assumed that their high level of sequence conservation implies a high level of expression conservation. A limited amount of data supports this, although discrepancies do exist. By comparing the expression of ≈ 100 miRNAs in medaka and chicken with existing data for zebrafish and mouse, we conclude that the timing and location of miRNA expression is not strictly conserved. In some instances, differences in expression are associated with changes in miRNA copy number, genomic context, or both between species. Variation in miRNA expression is more pronounced the greater the differences in physiology, and it is enticing to speculate that changes in miRNA expression may play a role in shaping the physiological differences produced during animal development.
机译：MicroRNA（miRNA）通过翻译抑制和mRNA降解来减弱基因表达。它们丰富，高度保守，并预计将调节大量的转录本。已知数百种miRNA类型，其中许多与细胞增殖和分化有关。许多表现出组织特异性表达，这有助于评估其功能，并且已经假定其高水平的序列保守性意味着高水平的表达保守性。尽管确实存在差异，但是数量有限的数据支持这一点。通过比较medaka和鸡中≈100个miRNA的表达与斑马鱼和小鼠的现有数据，我们得出结论，miRNA表达的时间和位置没有严格保守。在某些情况下，表达差异与物种之间miRNA拷贝数，基因组背景或两者的变化有关。生理上的差异越大，miRNA表达的变化就越明显，并且有理由推测，miRNA表达的变化可能在影响动物发育过程中产生的生理差异中起作用。

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