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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Acceleration of the recognition rate between grafted ligands and receptors with magnetic forces
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Acceleration of the recognition rate between grafted ligands and receptors with magnetic forces

机译：磁力促进嫁接的配体与受体之间的识别率

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摘要

When ligands and receptors are both attached on surfaces, because of the restriction of configurational freedom, their recognition kinetics may be substantially reduced as compared with freely diffusing species. In nature, this reduction may influence the efficiency of the capture and adhesion of circulating cells. Here we show that similar consequences are observed for colloids grafted with biomolecules that are used as probes for diagnostics. We exploit Brownian magnetic colloids that self-assemble into linear chains to show also that the resulting one-dimensional confinement considerably accelerates the recognition rate between grafted receptors and their ligands. We propose that because confinement significantly augments the colliding frequency, it also causes a large increase in the attempt frequency of the recognition. This work gives the basis of a rapid, homogeneous, and highly sensitive bioanalysis method.
机译：当配体和受体都附着在表面上时，由于构型自由的限制，与自由扩散的物种相比，它们的识别动力学可能会大大降低。实际上，这种减少可能会影响循环细胞的捕获和粘附效率。在这里，我们表明，对于嫁接到用作诊断探针的生物分子的胶体，观察到了相似的结果。我们利用自组装成线性链的布朗磁性胶体来证明所产生的一维限制极大地加快了嫁接受体及其配体之间的识别率。我们提出，由于限制会大大增加碰撞频率，因此也会导致识别尝试频率的大幅增加。这项工作为快速，均一且高度灵敏的生物分析方法奠定了基础。

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