Evolutionary theory for modifiers of epistasis using a general symmetric model

Liberman U; Feldman MW

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Evolutionary theory for modifiers of epistasis using a general symmetric model

机译：广义对称模型的上位修饰因子进化理论

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摘要

Genetic interactions in fitness are studied by using modifier theory. The effects on fitness of two linked genes are perturbed by alleles at a third linked locus that controls the extent of epistasis in fitness between the first two. This epistasis is determined by asymmetric interaction matrix, and it is shown that a modifier allele that increases epistasis will invade when the linkage between the other two genes is sufficiently tight and these genes are in linkage disequilibrium. With linkage equilibrium among the major loci, increased or decreased epistasis may evolve depending on the allele frequencies at these loci.

机译：利用修饰语理论研究了适应性中的遗传相互作用。等位基因在第三个连锁基因座处干扰了对两个连锁基因适应性的影响，该基因座控制了前两个连锁基因之间的适应性上位程度。该上位由非对称相互作用矩阵决定，并且显示出当其他两个基因之间的连接足够紧密并且这些基因处于连接不平衡状态时，增加上位的修饰等位基因将侵入。在主要基因座之间具有连锁平衡的情况下，取决于这些基因座处的等位基因频率，上位性可能会增加或减少。

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来源
《Proceedings of the National Academy of Sciences of the United States of America》 |2006年第51期|p. 19402-19406|共5页
作者
Liberman U; Feldman MW;
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作者单位

Stanford Univ, Dept Biol Sci, Stanford, CA 94305 USA;

Tel Aviv Univ, Sch Math Sci, IL-69978 Tel Aviv, Israel;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
关键词
modifier theory; linkage disequilibrium; symmetric viabilities; interaction matrix; external; GENETIC ARCHITECTURE; SELECTION; CANALIZATION; LINKAGE; RECOMBINATION; TRAITS; LOCI;

机译：修正理论;连锁不平衡;对称生存力;相互作用矩阵;外部;遗传结构;选择;归一化;连锁;重组;性状;LOCI;

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6. Evolutionary theory for modifiers of epistasis using a general symmetric model [O] . Uri Liberman, Marcus W. Feldman 2006

机译：广义对称模型的上位修饰因子进化理论
7. Evolutionary theory for modifiers of epistasis using a general symmetric model [O] . Liberman, Uri, Feldman, Marcus W. 2006

机译：广义对称模型的上位修饰因子进化理论

Evolutionary theory for modifiers of epistasis using a general symmetric model

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