...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Environmental change and infectious disease: How new roads affect the transmission of diarrheal pathogens in rural Ecuador
【24h】

Environmental change and infectious disease: How new roads affect the transmission of diarrheal pathogens in rural Ecuador

机译：环境变化和传染病：新道路如何影响厄瓜多尔农村腹泻病原体的传播

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Environmental change plays a large role in the emergence of infectious disease. The construction of a new road in a previously roadless area of northern coastal Ecuador provides a valuable natural experiment to examine how changes in the social and natural environment, mediated by road construction, affect the epidemiology of diarrheal diseases. Twenty-one villages were randomly selected to capture the full distribution of village population size and distance from a main road (remoteness), and these were compared with the major population center of the region, Elorbon, that lies on the road. Estimates of enteric pathogen infection rates were obtained from case-control studies at the village level. Higher rates of infection were found in nonremote vs. remote villages [pathogenic Escherichia coli: odds ratio (OR) = 8.4, confidence interval (CI) 1.6, 43.5; rotavirus: OR = 4.0, CI 1.3, 12.1; and Giardia: OR = 1.9, CI 1.3, 2.7]. Higher rates of all-cause diarrhea were found in Borbon compared with the 21 villages (RR = 2.0, CI 1.5, 2.8), as well as when comparing nonremote and remote villages (OR = 2.7, CI 1.5, 4.8). Social network data collected in parallel offered a causal link between remoteness and disease. The significant and consistent trends across viral, bacterial, and protozoan pathogens suggest the importance of considering a broad range of pathogens with differing epidemiological patterns when assessing the environmental impact of new roads. This study provides insight into the initial health impacts that roads have on communities and into the social and environmental processes that create these impacts.
机译：环境变化在传染病的发生中起着重要作用。在厄瓜多尔北部沿海地区以前没有道路的地区建造一条新道路，提供了宝贵的自然实验，以检验由道路建设介导的社会和自然环境的变化如何影响腹泻病的流行病学。随机选择了21个村庄，以捕获村庄人口规模和与主要道路（远程）的距离的完整分布，并将这些村庄与该地区主要人口中心Elorbon进行比较。肠道病原体感染率的估算是从村庄一级的病例对照研究中获得的。在非偏远乡村与偏远乡村中发现更高的感染率[致病性大肠杆菌：优势比（OR）= 8.4，置信区间（CI）1.6、43.5；轮状病毒：OR = 4.0，CI 1.3，12.1;和贾第虫病：OR = 1.9，CI 1.3，2.7]。与21个村庄相比（RR = 2.0，CI 1.5，2.8），以及与非偏远村庄和偏远村庄相比（OR = 2.7，CI 1.5，4.8），波旁的全因腹泻发生率更高。并行收集的社交网络数据提供了远程性与疾病之间的因果关系。病毒，细菌和原生动物病原体之间的显着且一致的趋势表明，在评估新道路的环境影响时，考虑具有不同流行病学模式的多种病原体非常重要。这项研究可以洞悉道路对社区的最初健康影响，以及造成这些影响的社会和环境过程。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号