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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Delay of T cell senescence by caloric restriction in aged long-lived nonhuman primates
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Delay of T cell senescence by caloric restriction in aged long-lived nonhuman primates

机译：高龄长寿非人类灵长类动物受热量限制而延迟T细胞衰老

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摘要

Caloric restriction (CR) has long been known to increase median and maximal lifespans and to decreases mortality and morbidity in short-lived animal models, likely by altering fundamental biological processes that regulate aging and longevity. in rodents, CR was reported to delay the aging of the immune system (immune senescence), which is believed to be largely responsible for a dramatic increase in age-related susceptibility to infectious diseases. However, it is unclear whether CR can exert similar effects in long-lived organisms. Previous studies involving 2- to 4-year CR treatment of long-lived primates failed to find a CR effect or reported effects on the immune system opposite to those seen in CR-treated rodents. Here we show that long-term CR delays the adverse effects of aging on nonhuman primate T cells. CR effected a marked improvement in the maintenance and/or production of naive T cells and the consequent preservation of T cell receptor repertoire diversity. Furthermore, CR also improved T cell function and reduced production of inflammatory cytokines by memory T cells. Our results provide evidence that CR can delay immune senescence in nonhuman primates, potentially contributing to an extended lifespan by reducing susceptibility to infectious disease.
机译：长期以来，已知热量限制（CR）可以增加寿命的中位数和最大寿命，并降低短期动物模型的死亡率和发病率，这可能是通过改变调节衰老和长寿的基本生物学过程来实现的。在啮齿动物中，据报道CR会延缓免疫系统的衰老（免疫衰老），这被认为是导致与年龄相关的传染病易感性急剧增加的原因。然而，目前还不清楚CR是否可以在长寿生物中发挥类似作用。先前涉及长寿灵长类动物2到4年CR治疗的研究未能发现CR效应或报告的免疫系统效应与CR啮齿类动物所见相反。在这里，我们显示长期的CR可以延缓衰老对非人类灵长类T细胞的不利影响。 CR显着改善了天然T细胞的维持和/或生产，并因此保留了T细胞受体库的多样性。此外，CR还改善了T细胞功能，并减少了记忆T细胞产生的炎性细胞因子。我们的结果提供了证据，证明CR可以延迟非人类灵长类动物的免疫衰老，并可能通过降低对传染病的易感性来延长寿命。

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