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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >Circulating factors induced by caloric restriction in the nonhuman primate macaca mulatta activate angiogenic processes in endothelial cells
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Circulating factors induced by caloric restriction in the nonhuman primate macaca mulatta activate angiogenic processes in endothelial cells

机译：非人灵长类猕猴受热量限制诱导的循环因子激活内皮细胞的血管生成过程

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Moderate caloric restriction (CR) without malnutrition increases healthspan in virtually every species studied, including nonhuman primates. In mice, CR exerts significant microvascular protective effects resulting in increased microvascular density in the heart and the brain, which likely contribute to enhanced tolerance to ischemia and improved cardiac performance and cognitive function. Yet, the underlying mechanisms by which CR confer microvascular protection remain elusive. To test the hypothesis that circulating factors triggered by CR regulate endothelial angiogenic capacity, we treated cultured human endothelial cells with sera derived from Macaca mulatta on long-term (over 10 years) CR. Cells treated with sera derived from ad-libitum-fed control monkeys served as controls. We found that factors present in CR sera upregulate vascular endothelial growth factor (VEGF) signaling and stimulate angiogenic processes, including endothelial cell proliferation and formation of capillary-like structures. Treatment with CR sera also tended to increase cellular migration (measured by a wound-healing assay using electric cell-substrate impedance sensing [ECIS] technology) and adhesion to collagen. Collectively, we find that circulating factors induced by CR promote endothelial angiogenic processes, suggesting that increased angiogenesis may be a potential mechanism by which CR improves cardiac function and prevents vascular cognitive impairment. ? 2012 The Author.
机译：几乎没有研究到的每个物种（包括非人类灵长类动物）的适度热量限制（CR）都能增加健康寿命。在小鼠中，CR发挥了显着的微血管保护作用，导致心脏和大脑的微血管密度增加，这可能有助于增强对缺血的耐受性并改善心脏性能和认知功能。然而，CR赋予微血管保护的基本机制仍然难以捉摸。为了检验由CR触发的循环因子调节内皮血管生成能力的假说，我们在长期（超过10年）的CR中用源自猕猴的血清处理了培养的人内皮细胞。用来自随意喂养的对照猴子的血清处理的细胞作为对照。我们发现存在于CR血清中的因子会上调血管内皮生长因子（VEGF）信号并刺激血管生成过程，包括内皮细胞增殖和毛细血管样结构的形成。 CR血清的治疗还倾向于增加细胞迁移（通过使用电细胞基质阻抗传感[ECIS]技术的伤口愈合测定法测量）和对胶原的粘附。集体地，我们发现由CR诱导的循环因子促进内皮血管生成过程，这表明增加的血管生成可能是CR改善心脏功能并防止血管认知障碍的潜在机制。 ？ 2012作者。

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