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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Single-stranded nucleic acid-induced helical self-assembly of alkynylplatinum(Ⅱ) terpyridyl complexes
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Single-stranded nucleic acid-induced helical self-assembly of alkynylplatinum(Ⅱ) terpyridyl complexes

机译：单链核酸诱导的炔丙基铂（Ⅱ）三联吡啶配合物螺旋自组装

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摘要

Single-stranded nucleic acids, which carry multiple negative charges in an aqueous medium at near neutral pH, are found to induce the aggregation and self-assembly of the positively charged alkynylplatinum(Ⅱ) terpyridyl complexes via electrostatic binding of the platinum complexes to the single-stranded nucleic acids, as revealed by the appearance of new UV-vis absorption and emission bands upon addition of single-stranded nucleic acids to a buffer solution of the complex. Changes in the intensity and pattern of circular dichroism (CD) spectroscopy are also observed, many of which are consistent with the assembly of the platinum complexes into helical structures, via metal···metal and π···π stacking interactions. The induced spectroscopic property changes are found to depend on the structural properties of the nucleic acids.
机译：发现在近中性pH值的水性介质中带有多个负电荷的单链核酸通过铂络合物与单个化合物的静电结合诱导正电荷的炔基铂（Ⅱ）吡啶基络合物的聚集和自组装。如通过将单链核酸添加到复合物的缓冲溶液中时新的UV-vis吸收和发射带的出现所揭示的，显示出双链核酸。还观察到圆二色性（CD）光谱的强度和图案的变化，其中许多与通过金属···金属和π···π堆积相互作用将铂络合物组装成螺旋结构一致。发现诱导的光谱性质变化取决于核酸的结构性质。

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