Structural transitions of complement component C3 and its activation products

Noritaka Nishida; Thomas Walz; Timothy A. Springer

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Structural transitions of complement component C3 and its activation products

机译：补体成分C3及其激活产物的结构转变

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Complement sensitizes pathogens for phagocytosis and lysis. We use electron microscopy to examine the structural transitions in the activation of the pivotal protein in the complement pathway, C3. In the cleavage product C3b, the position of the thioester domain moves ≈100 A, which becomes covalently coupled to antigenic surfaces. In the iC3b fragment, cleavage in an intervening domain creates a long flexible linker between the thioester domain and the macroglobulin domain ring of C3. Studies on two products of nucleophile addition to C3 reveal a structural intermediate in activation, and a final product, in which the anaphylatoxin domain has undergone a remarkable movement through the macroglobulin ring.

机译：补体使病原体对吞噬作用和裂解敏感。我们使用电子显微镜检查补体途径C3中关键蛋白的激活中的结构转变。在裂解产物C3b中，硫酯结构域的位置移动≈100A，它与抗原表面共价偶联。在iC3b片段中，在中间结构域中的切割在C3的硫酯结构域和巨球蛋白结构域环之间产生了一个长的柔性接头。对添加到C3的亲核试剂的两种产物的研究揭示了激活的结构中间体和最终产物，其中过敏毒素域通过巨球蛋白环经历了显着运动。

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《Proceedings of the National Academy of Sciences of the United States of America》 |2006年第52期|p.19737-19742|共6页
作者
Noritaka Nishida; Thomas Walz; Timothy A. Springer;
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作者单位

CBR Institute for Biomedical Research, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
关键词
electron microscopy; proteolytic; thioester;

机译：电子显微镜;蛋白水解;硫酯;

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1. C3a and C3b Activation Products of the Third Component of Complement (C3) Are Critical for Normal Liver Recovery after Toxic Injury [J] . Maciej M. Markiewski, Dimitrios Mastellos, Ruxandra Tudoran, The journal of immunology . 2004,第2期

机译：补体第三部分（C3）的C3a和C3b活化产物对于中毒损伤后的正常肝恢复至关重要
2. C3a and C3b Activation Products of the Third Component of Complement (C3) Are Critical for Normal Liver Recovery after Toxic Injury [J] . Maciej M. Markiewski, Dimitrios Mastellos, Ruxandra Tudoran, The journal of immunology . 2004,第2期

机译：补体第三部分（C3）的C3a和C3b活化产物对于中毒损伤后的正常肝恢复至关重要
3. C3a and C3b Activation Products of the Third Component of Complement(C3)Are Critical for Normal Liver Recovery after Toxic Injury [J] . Maciej M.Markiewski, Dimitrios Mastellos, Ruxandra Tudoran, The Journal of Immunology: Official Journal of the American Association of Immunologists . 2004,第2期

机译：补体（C3）第三成分的C3a和C3b激活产物对于中毒损伤后的正常肝恢复至关重要
4. C3a and C4a: Complement Split Products Identify Patients with Hyperacute Lyme Disease [C] . R. Shoemaker, P. Giclas, C. Crowder, Collegium Internationale Allergologicum . 2007

机译：C3A和C4A：补体分裂产品鉴定患有超敏性莱姆病的患者
5. Generation of Multiple Fluid-Phase C3b:Plasma Protein Complexes During Complement Activation. Functional Significance and Possible Implications in C3 Glomerulopathies. [D] . Ramadass, Mahalakshmi. 2013

机译：补体激活过程中多个液相C3b：血浆蛋白复合物的产生。 C3肾小球病变的功能意义和可能意义。
6. Structural transitions of complement component C3 and its activation products [O] . Noritaka Nishida, Thomas Walz, Timothy A. Springer 2006

机译：补体成分C3及其激活产物的结构转变
7. Structural transitions of complement component C3 and its activation products [O] . Nishida, Noritaka, Walz, Thomas, Springer, Timothy A. 2006

机译：补体成分C3及其激活产物的结构转变

Structural transitions of complement component C3 and its activation products

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