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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Reactive oxygen signaling and MAPK activation distinguish Epstein-Barr Virus (EBV)-positive versus EBV-negative Burkitt's lymphoma.
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Reactive oxygen signaling and MAPK activation distinguish Epstein-Barr Virus (EBV)-positive versus EBV-negative Burkitt's lymphoma.

机译：活性氧信号和MAPK激活可区分爱泼斯坦-巴尔病毒（EBV）阳性与EBV阴性的伯基特氏淋巴瘤。

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摘要

Burkitt's lymphoma (BL) is an aggressive B cell neoplasm, which is one of the most common neoplasms of childhood. It is highly widespread in East Africa, where it appears in endemic form associated with Epstein-Barr virus (EBV) infection, and around the world in a sporadic form in which EBV infection is much less common. In addition to being the first human neoplasm to be associated with EBV, BL is associated with a characteristic translocation, in which the Ig promoter is translocated to constitutively activate the c-myc oncogene. Although many BLs respond well to chemotherapy, a significant fraction fails to respond to therapy, leading to death. In this article, we demonstrate that EBV-positive BL expresses high levels of activated mitogen-activated protein kinase and reactive oxygen species (ROS), and that ROS directly regulate NF-kappaB activation. EBV-negative BLs exhibit activation of phosphoinositol 3-kinase, but do not have elevated levels of ROS. Elevated reactive oxygen may play a role in diverse forms of viral carcinogenesis in humans, including cancers caused by EBV, hepatitis B, C, and human T cell lymphotropic virus. Our findings imply that inhibition of ROS may be useful in the treatment of EBV-induced neoplasia.
机译：伯基特淋巴瘤（BL）是一种侵袭性B细胞肿瘤，是儿童最常见的肿瘤之一。它在东非非常普遍，在那里以与爱泼斯坦-巴尔病毒（EBV）感染相关的地方性形式出现，在世界各地以零星形式出现，其中EBV感染很少见。除了是第一个与EBV相关的人类肿瘤外，BL还与特征性易位相关，其中Ig启动子易位以组成性激活c-myc癌基因。尽管许多BL对化疗反应良好，但很大一部分对治疗无效，导致死亡。在本文中，我们证明了EBV阳性BL表达高水平的激活的促分裂原激活的蛋白激酶和活性氧（ROS），并且ROS直接调节NF-κB的激活。 EBV阴性的BL表现出磷酸肌醇3激酶的激活，但没有升高的ROS水平。活性氧升高可能在人类各种形式的病毒致癌过程中发挥作用，包括由EBV，B，C，C型肝炎和人类T细胞淋巴病毒引起的癌症。我们的发现表明，抑制ROS可能在EBV诱导的瘤形成的治疗中有用。

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