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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Assessment of tumor characteristic gene expression in cell lines using a tissue similarity index (TSI).
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Assessment of tumor characteristic gene expression in cell lines using a tissue similarity index (TSI).

机译：使用组织相似性指数（TSI）评估细胞系中肿瘤特征基因的表达。

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摘要

The gene expression profiles of 60 cell lines, derived from nine different tissues, were compared with their corresponding in vivo tumors and tissues. Cell lines expressed few tissue-specific (2%) or tumor-specific (5%) genes when analyzed group-wise. A tissue similarity index (TSI) was designed based upon singular value decomposition that measured in vivo tumor characteristic gene expression in each cell line independently. Only 34 of the 60 cell lines received the highest TSI toward its tumor of origin. In addition, we identified the most appropriate cell lines to be used as model systems for different in vivo tumors. Seven cell lines were identified as being of another origin than the originally presumed one. The proposed TSI will likely become an important tool for the selection of the most appropriate cell lines in pharmaceutical screening programs and experimental and biomedical research.
机译：将来自九种不同组织的60种细胞系的基因表达谱与其相应的体内肿瘤和组织进行了比较。逐组分析时，细胞系表达的组织特异性基因（2％）或肿瘤特异性基因（5％）很少。基于奇异值分解设计组织相似性指数（TSI），该奇异值分解可独立测量每个细胞系中的体内肿瘤特征基因表达。 60个细胞系中只有34个在其原发肿瘤中获得最高的TSI。此外，我们确定了最适合用作不同体内肿瘤模型系统的细胞系。七种细胞系被鉴定为不同于最初推测的一种。拟议的TSI可能会成为在药物筛选程序以及实验和生物医学研究中选择最合适的细胞系的重要工具。

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